A glimpse into the past of Hansen's disease – Re-evaluation and comparative analysis of cases with leprosy from the Avar period of the Trans-Tisza region, Hungary

IF 2.8 3区 医学 Q3 IMMUNOLOGY Tuberculosis Pub Date : 2024-07-31 DOI:10.1016/j.tube.2024.102552
Balázs Tihanyi , Levente Samu , István Koncz , Kristóf Hergott , Pál Medgyesi , György Pálfi , Krisztina Ágnes Szabó , Luca Kis , Antónia Marcsik , Erika Molnár , Olga Spekker
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Abstract

Our knowledge of how society viewed leprosy and treated its victims in the past is still scarce, especially in geographical regions and archaeological periods from where no written sources are available. To fill in some research gaps, we provide the comparative analysis of five previously described, probable cases with leprosy from the Avar-period Trans-Tisza region (Hungary). The five skeletons were subject to a detailed macromorphological (re-)evaluation. Where possible, the biological and social consequences of having leprosy were reconstructed based on the observed bony changes and mortuary treatment, respectively. The retrospective, macromorphology-based diagnosis of leprosy could be established in three cases only. Based on the detected skeletal lesions, all of them suffered from near-lepromatous or lepromatous leprosy. The disease resulted in aesthetic repercussions and functional implications, which would have been disadvantageous for these individuals, and limited or changed their possibilities to participate in social situations. They could have even required heavy time investment from their respective communities. The analysis of the mortuary treatment of the confirmed leprosy cases revealed no evidence of a social stigma. These findings indicate that the afflicted have not been systematically expulsed or segregated, at least in death, in the Early Middle Ages of the Carpathian Basin.

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汉森氏病的过去一瞥--对匈牙利外蒂萨地区阿瓦尔时期麻风病病例的重新评估和比较分析
我们对过去社会如何看待麻风病以及如何对待麻风病人的了解仍然很少,尤其是在没有书面资料的地理区域和考古时期。为了填补一些研究空白,我们对阿瓦尔时期跨蒂萨地区(匈牙利)的五具以前描述过的麻风病疑似病例进行了比较分析。我们对这五具骸骨进行了详细的大形态学(重新)评估。在可能的情况下,根据观察到的骨骼变化和停尸治疗,分别重建了麻风病的生物学和社会后果。仅在三个病例中可以确定基于大形态学的麻风病回顾性诊断。根据检测到的骨骼病变,他们都患有近麻风或麻风病。麻风病会影响美观和功能,对这些人不利,限制或改变他们参与社会活动的可能性。他们甚至可能需要各自社区投入大量时间。对确诊麻风病例停尸治疗的分析表明,没有证据表明麻风病人会受到社会鄙视。这些研究结果表明,在喀尔巴阡山盆地的中世纪早期,麻风病人至少在死亡时没有被系统地驱逐或隔离。
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来源期刊
Tuberculosis
Tuberculosis 医学-呼吸系统
CiteScore
4.60
自引率
3.10%
发文量
87
审稿时长
49 days
期刊介绍: Tuberculosis is a speciality journal focusing on basic experimental research on tuberculosis, notably on bacteriological, immunological and pathogenesis aspects of the disease. The journal publishes original research and reviews on the host response and immunology of tuberculosis and the molecular biology, genetics and physiology of the organism, however discourages submissions with a meta-analytical focus (for example, articles based on searches of published articles in public electronic databases, especially where there is lack of evidence of the personal involvement of authors in the generation of such material). We do not publish Clinical Case-Studies. Areas on which submissions are welcomed include: -Clinical TrialsDiagnostics- Antimicrobial resistance- Immunology- Leprosy- Microbiology, including microbial physiology- Molecular epidemiology- Non-tuberculous Mycobacteria- Pathogenesis- Pathology- Vaccine development. This Journal does not accept case-reports. The resurgence of interest in tuberculosis has accelerated the pace of relevant research and Tuberculosis has grown with it, as the only journal dedicated to experimental biomedical research in tuberculosis.
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