Trabecular bone score assessed by dual-energy X ray absorption predicts vertebral fractures in HIV infected young adults

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Bone Reports Pub Date : 2024-08-13 DOI:10.1016/j.bonr.2024.101797
Teresa Mannarino , Adriana D'Antonio , Simona Mercinelli , Maria Falzarano , Federica Volpicelli , Ciro Gabriele Mainolfi , Emanuela Zappulo , Giovanni Di Filippo , Maria Rosaria Cotugno , Ivan Gentile , Alberto Cuocolo
{"title":"Trabecular bone score assessed by dual-energy X ray absorption predicts vertebral fractures in HIV infected young adults","authors":"Teresa Mannarino ,&nbsp;Adriana D'Antonio ,&nbsp;Simona Mercinelli ,&nbsp;Maria Falzarano ,&nbsp;Federica Volpicelli ,&nbsp;Ciro Gabriele Mainolfi ,&nbsp;Emanuela Zappulo ,&nbsp;Giovanni Di Filippo ,&nbsp;Maria Rosaria Cotugno ,&nbsp;Ivan Gentile ,&nbsp;Alberto Cuocolo","doi":"10.1016/j.bonr.2024.101797","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Bone mineral density (BMD) is reduced in patients with human immunodeficiency virus (HIV) infection. Trabecular bone score (TBS) is an additional feature calculated by dual-energy X ray absorption (DXA) that measures texture inhomogeneity at lumbar spine level, providing an index of bone microarchitecture. However, its clinical value still needs to be fully addressed. Aims of the study were to assess BMD and TBS in a cohort of patients with HIV compared to a population of healthy subjects and to investigate the prognostic value of TBS in HIV infected patients.</p></div><div><h3>Method</h3><p>Bone health was assessed by DXA in 165 patients with HIV infection (120 men, mean age 40 ± 7 years) and in 164 healthy subjects (53 male, mean age 37 ± 10 years). BMD was measured at level of lumbar spine (L1-L4), femoral neck and total hip. TBS was computed from the images of lumbar spine using machine proprietary software.</p></div><div><h3>Results</h3><p>BMD at femoral neck level was similar in HIV infected patients and healthy subjects (<em>p</em> = 0.57), whereas BMD measured in total femur was lower in HIV infected patients compared to healthy subjects (<em>p</em> &lt; 0.05). Although mean BMD in lumbar spine was similar between HIV infected patients and healthy subjects (<em>p</em> = 0.90), mean lumbar TBS was lower in patients with HIV infection compared to healthy subjects (<em>p</em> &lt; 0.05). Age, sex and HIV infection resulted independent predictors of reduced TBS. In HIV infected patients age, sex and protease inhibitor duration resulted independent predictors of reduced TBS. TBS was a significant predictor of vertebral fractures during follow-up (<em>p</em> &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>Patients with HIV infection have a significant reduction of TBS, a texture parameter related to bone microarchitecture that may provide skeletal information that is not captured from the standard BMD measurement.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"22 ","pages":"Article 101797"},"PeriodicalIF":2.1000,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000640/pdfft?md5=77cc61c34ab5a365ce5712922ea486e0&pid=1-s2.0-S2352187224000640-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bone Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352187224000640","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction

Bone mineral density (BMD) is reduced in patients with human immunodeficiency virus (HIV) infection. Trabecular bone score (TBS) is an additional feature calculated by dual-energy X ray absorption (DXA) that measures texture inhomogeneity at lumbar spine level, providing an index of bone microarchitecture. However, its clinical value still needs to be fully addressed. Aims of the study were to assess BMD and TBS in a cohort of patients with HIV compared to a population of healthy subjects and to investigate the prognostic value of TBS in HIV infected patients.

Method

Bone health was assessed by DXA in 165 patients with HIV infection (120 men, mean age 40 ± 7 years) and in 164 healthy subjects (53 male, mean age 37 ± 10 years). BMD was measured at level of lumbar spine (L1-L4), femoral neck and total hip. TBS was computed from the images of lumbar spine using machine proprietary software.

Results

BMD at femoral neck level was similar in HIV infected patients and healthy subjects (p = 0.57), whereas BMD measured in total femur was lower in HIV infected patients compared to healthy subjects (p < 0.05). Although mean BMD in lumbar spine was similar between HIV infected patients and healthy subjects (p = 0.90), mean lumbar TBS was lower in patients with HIV infection compared to healthy subjects (p < 0.05). Age, sex and HIV infection resulted independent predictors of reduced TBS. In HIV infected patients age, sex and protease inhibitor duration resulted independent predictors of reduced TBS. TBS was a significant predictor of vertebral fractures during follow-up (p < 0.05).

Conclusion

Patients with HIV infection have a significant reduction of TBS, a texture parameter related to bone microarchitecture that may provide skeletal information that is not captured from the standard BMD measurement.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
通过双能 X 射线吸收评估的骨小梁得分可预测感染艾滋病毒的年轻成人的脊椎骨折情况
导言人类免疫缺陷病毒(HIV)感染患者的骨矿物质密度(BMD)会降低。骨小梁评分(TBS)是通过双能量 X 射线吸收(DXA)计算得出的额外特征,可测量腰椎水平的纹理不均匀性,提供骨微结构指数。然而,其临床价值仍有待充分研究。该研究的目的是评估一组艾滋病毒感染者与健康受试者的 BMD 和 TBS,并研究 TBS 在艾滋病毒感染者中的预后价值。方法通过 DXA 评估 165 名艾滋病毒感染者(120 名男性,平均年龄为 40 ± 7 岁)和 164 名健康受试者(53 名男性,平均年龄为 37 ± 10 岁)的骨骼健康状况。对腰椎(L1-L4)、股骨颈和全髋关节的 BMD 进行了测量。结果 HIV 感染者和健康受试者股骨颈水平的 BMD 相似(p = 0.57),而 HIV 感染者与健康受试者相比,股骨全长的 BMD 较低(p <0.05)。虽然 HIV 感染者和健康受试者的腰椎平均 BMD 值相似(p = 0.90),但 HIV 感染者的腰椎平均 TBS 值低于健康受试者(p <0.05)。年龄、性别和艾滋病毒感染是 TBS 降低的独立预测因素。在 HIV 感染者中,年龄、性别和蛋白酶抑制剂持续时间是 TBS 降低的独立预测因素。TBS是随访期间脊椎骨折的重要预测指标(p < 0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Bone Reports
Bone Reports Medicine-Orthopedics and Sports Medicine
CiteScore
4.30
自引率
4.00%
发文量
444
审稿时长
57 days
期刊介绍: Bone Reports is an interdisciplinary forum for the rapid publication of Original Research Articles and Case Reports across basic, translational and clinical aspects of bone and mineral metabolism. The journal publishes papers that are scientifically sound, with the peer review process focused principally on verifying sound methodologies, and correct data analysis and interpretation. We welcome studies either replicating or failing to replicate a previous study, and null findings. We fulfil a critical and current need to enhance research by publishing reproducibility studies and null findings.
期刊最新文献
The biological function of integrin-linked kinase on bone formation A novel SGMS2 mutation associated with high bone mass; description of an affected family with recurrent fragility fractures Biomechanical influence of numerical variants of lumbosacral transitional vertebra with Castellvi type I on adjacent discs and facet joints based on 3D finite element analysis Total talectomy and reconstruction using unrestricted 3D printed prosthesis for pediatric talus hemangioendothelioma Heterotopic ossification (HO) prophylaxis in total hip arthroplasty (THA): A systematic review of level I and level II evidence since 2000
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1