Effects of smoking cessation on endothelial function as assessed by flow-mediated total dilation.

IF 1.9 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Ultrasound Pub Date : 2024-08-14 DOI:10.1186/s12947-024-00329-9

Naoki Okuyama, Kazuo Fukumoto, Yasuhiko Takemoto, Takeshi Yamauchi, Ayako Makuuchi, Hiroki Namikawa, Hiromitsu Toyoda, Yoshihiro Tochino, Yasuhiro Izumiya, Daiju Fukuda, Taichi Shuto

{"title":"Effects of smoking cessation on endothelial function as assessed by flow-mediated total dilation.","authors":"Naoki Okuyama, Kazuo Fukumoto, Yasuhiko Takemoto, Takeshi Yamauchi, Ayako Makuuchi, Hiroki Namikawa, Hiromitsu Toyoda, Yoshihiro Tochino, Yasuhiro Izumiya, Daiju Fukuda, Taichi Shuto","doi":"10.1186/s12947-024-00329-9","DOIUrl":null,"url":null,"abstract":"Background: In assessing the effects of smoking cessation on endothelial function, low-flow-mediated constriction (L-FMC) may provide complementary information to flow-mediated dilation (FMD). However, the value of flow-mediated total dilation (FMTD), an index that incorporates L-FMC into FMD, remains underreported. We aimed to evaluate the effect of smoking cessation on endothelial function, as assessed by FMD and FMTD, and clarify its associated clinical factors.Methods: We enrolled 118 consecutive current smokers without previous coronary artery disease (72.9% were men; age: 59 ± 11 years) who underwent smoking cessation treatment. The clinical variables %FMD, %L-FMC, and %FMTD were examined before and 20 weeks after treatment initiation. A multivariate linear regression model was used to investigate the effects of smoking cessation on %FMD and %FMTD and the interaction between smoking cessation and baseline clinical variables.Results: After 20 weeks, 85 smokers (69.4% were men; age: 59 ± 12 years) ceased smoking (abstainers), whereas 33 smokers (81.8% were men; age: 58 ± 11 years) did not (continued smokers). The estimated group differences (abstainers - continued smokers) in changes in the %FMD and %FMTD were 0.77% (95% confidence interval [CI], -0.22-1.77%; p = 0.129) and 1.17% (95% CI, 0.16-2.18%; p = 0.024), respectively. Smoking cessation-associated improvement in %FMTD was greater in women than in men (5.41% [95% CI, 3.15-7.67%] versus 0.24% [95% CI, -0.81-1.28%]; p-value for interaction, < 0.001). Additionally, a greater %FMTD improvement was observed in patients who smoked fewer cigarettes per day (p-value for interaction, 0.042) and those who had a smaller resting baseline lumen diameter (Dbase) (p-value for interaction, 0.023).Conclusions: Smoking cessation was associated with an improvement in %FMTD. Sex, cigarettes smoked per day, and Dbase significantly affected this improvement. The FMTD may help in risk stratification after smoking cessation.","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"22 1","pages":"11"},"PeriodicalIF":1.9000,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323354/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular Ultrasound","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12947-024-00329-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: In assessing the effects of smoking cessation on endothelial function, low-flow-mediated constriction (L-FMC) may provide complementary information to flow-mediated dilation (FMD). However, the value of flow-mediated total dilation (FMTD), an index that incorporates L-FMC into FMD, remains underreported. We aimed to evaluate the effect of smoking cessation on endothelial function, as assessed by FMD and FMTD, and clarify its associated clinical factors.

Methods: We enrolled 118 consecutive current smokers without previous coronary artery disease (72.9% were men; age: 59 ± 11 years) who underwent smoking cessation treatment. The clinical variables %FMD, %L-FMC, and %FMTD were examined before and 20 weeks after treatment initiation. A multivariate linear regression model was used to investigate the effects of smoking cessation on %FMD and %FMTD and the interaction between smoking cessation and baseline clinical variables.

Results: After 20 weeks, 85 smokers (69.4% were men; age: 59 ± 12 years) ceased smoking (abstainers), whereas 33 smokers (81.8% were men; age: 58 ± 11 years) did not (continued smokers). The estimated group differences (abstainers - continued smokers) in changes in the %FMD and %FMTD were 0.77% (95% confidence interval [CI], -0.22-1.77%; p = 0.129) and 1.17% (95% CI, 0.16-2.18%; p = 0.024), respectively. Smoking cessation-associated improvement in %FMTD was greater in women than in men (5.41% [95% CI, 3.15-7.67%] versus 0.24% [95% CI, -0.81-1.28%]; p-value for interaction, < 0.001). Additionally, a greater %FMTD improvement was observed in patients who smoked fewer cigarettes per day (p-value for interaction, 0.042) and those who had a smaller resting baseline lumen diameter (D_base) (p-value for interaction, 0.023).

Conclusions: Smoking cessation was associated with an improvement in %FMTD. Sex, cigarettes smoked per day, and D_base significantly affected this improvement. The FMTD may help in risk stratification after smoking cessation.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

通过血流介导的总扩张来评估戒烟对内皮功能的影响。

背景：在评估戒烟对血管内皮功能的影响时，低流量介导收缩（L-FMC）可为血流介导扩张（FMD）提供补充信息。然而，将低流量介导收缩（L-FMC）纳入 FMD 的指标--流量介导总扩张（FMTD）的价值仍未得到充分报道。我们旨在通过 FMD 和 FMTD 评估戒烟对内皮功能的影响，并明确其相关临床因素：我们连续招募了 118 名既往无冠状动脉疾病的吸烟者（72.9% 为男性；年龄：59 ± 11 岁），他们都接受了戒烟治疗。在治疗开始前和治疗开始后 20 周，对临床变量 %FMD、%L-FMC 和 %FMTD 进行了检测。采用多变量线性回归模型研究戒烟对 FMD% 和 FMTD% 的影响，以及戒烟与基线临床变量之间的交互作用：20 周后，85 名吸烟者（69.4% 为男性；年龄：59 ± 12 岁）停止吸烟（戒烟者），而 33 名吸烟者（81.8% 为男性；年龄：58 ± 11 岁）没有停止吸烟（继续吸烟者）。戒烟者与继续吸烟者在 FMD% 和 FMTD% 变化上的估计组间差异分别为 0.77%（95% 置信区间 [CI]，-0.22-1.77%；p = 0.129）和 1.17%（95% 置信区间，0.16-2.18%；p = 0.024）。女性与戒烟相关的FMTD%改善幅度大于男性（5.41% [95% CI, 3.15-7.67%] 对 0.24% [95% CI, -0.81-1.28%]；交互作用的p值为基数）（交互作用的p值为0.023）：结论：戒烟与FMTD%的改善有关。结论：戒烟与 FMTD 百分比的改善有关，性别、每天吸烟支数和 Dbase 对这一改善有显著影响。FMTD 可能有助于戒烟后的风险分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Cardiovascular Ultrasound CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cardiovascular Ultrasound is an online journal, publishing peer-reviewed: original research; authoritative reviews; case reports on challenging and/or unusual diagnostic aspects; and expert opinions on new techniques and technologies. We are particularly interested in articles that include relevant images or video files, which provide an additional dimension to published articles and enhance understanding. As an open access journal, Cardiovascular Ultrasound ensures high visibility for authors in addition to providing an up-to-date and freely available resource for the community. The journal welcomes discussion, and provides a forum for publishing opinion and debate ranging from biology to engineering to clinical echocardiography, with both speed and versatility.