Expression of Matrix Metalloproteinase-3 in the Aqueous Humor of Patients with Posner-Schlossman Syndrome.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY Current Eye Research Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI:10.1080/02713683.2024.2374840

Yu Liu, Xiangmei Kong, Jisen Teng, Zhujian Wang, Wenjun Cao

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Abstract

Purpose: To explore the expression of matrix metalloproteinase-3 (MMP-3) in the aqueous humor of patients with Posner-Schlossman syndrome (PSS), and the association between MMP-3 and PSS.

Methods: Peripheral blood and aqueous humor were routinely collected from 29 patients with PSS (PSS group) and 30 patients with age-related-cataract (ARC) (control group). The content of MMP-3 in serum and aqueous humor was measured by immunoturbidimetry. The correlation between MMP-3 and ophthalmic examination results were verified by Spearman's correlation analysis.

Results: The MMP-3 level in the aqueous humor of the PSS group was (25.86 ± 13.4)ng/ml, significantly higher than that in the control group (3.9 ± 2.7)ng/ml(p < 0.001), while there was no significant difference in serum MMP-3 level between the two groups (p = 0.125). The endothelial cell density (ECD) in the aqueous humor of the PSS group was (2078 ± 440) cell/mm², intraocular pressure (IOP) in the aqueous humor of the PSS group was (33 ± 12) mmHg. The correlation analysis of aqueous humor MMP-3 and various ophthalmic examination results showed that aqueous humor MMP-3 had a moderate correlation with IOP and the difference in ECD between the affected eye and the fellow eye.

Conclusions: MMP-3 level is elevated in the aqueous humor of PSS patients, and it may play an important role in the pathogenesis of PSS.

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Posner-Schlossman 综合征患者眼液中基质金属蛋白酶-3 的表达。

目的：探讨基质金属蛋白酶-3（MMP-3）在波斯纳-施洛斯曼综合征（PSS）患者眼房水中的表达，以及MMP-3与PSS之间的关联：方法：常规收集 29 名 PSS 患者（PSS 组）和 30 名老年性白内障患者（对照组）的外周血和房水。采用免疫比浊法测定血清和眼房水中 MMP-3 的含量。通过斯皮尔曼相关分析验证了 MMP-3 与眼科检查结果之间的相关性：结果：PSS 组眼底 MMP-3 水平为（25.86 ± 13.4）ng/ml，显著高于对照组（3.9 ± 2.7）ng/ml（P = 0.125）。PSS 组眼房水内皮细胞密度（ECD）为（2078 ± 440）个/mm2，眼压（IOP）为（33 ± 12）mmHg。眼房水 MMP-3 与各种眼科检查结果的相关性分析表明，眼房水 MMP-3 与眼压以及患眼与同侧眼的 ECD 差异呈中度相关：结论：PSS 患者的眼房水 MMP-3 水平升高，可能在 PSS 的发病机制中扮演重要角色。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Eye Research 医学-眼科学

CiteScore

4.60

自引率

0.00%

发文量

163

审稿时长

12 months

期刊介绍： The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.