Unveiling the nexus: Long non-coding RNAs and the PI3K/Akt pathway in oral squamous cell carcinoma

IF 2.9 4区 医学 Q2 PATHOLOGY Pathology, research and practice Pub Date : 2024-08-12 DOI:10.1016/j.prp.2024.155540
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Abstract

The PI3K/Akt pathway plays a critical role in the progression and treatment of oral squamous cell carcinoma (OSCC). Recent research has uncovered the involvement of long non-coding RNAs (lncRNAs) in regulating this pathway, influencing OSCC cell proliferation, survival, and metastasis. This review explores the latest findings on how certain lncRNAs act as either cancer promoters or cancer inhibitors within the PI3K/Akt signaling pathway. Certain lncRNAs act as oncogenic or tumor-suppressive agents, making them potential diagnostic and prognostic markers. Targeting these lncRNAs may lead to novel therapeutic strategies. The evolving fields of precision medicine and artificial intelligence promise advancements in OSCC diagnosis and treatment, enabling more personalized and effective patient care.

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揭开联系的面纱:长非编码 RNA 与口腔鳞状细胞癌中的 PI3K/Akt 通路。
PI3K/Akt 通路在口腔鳞状细胞癌(OSCC)的进展和治疗中起着至关重要的作用。最近的研究发现,长非编码 RNA(lncRNA)参与了该通路的调控,影响了 OSCC 细胞的增殖、存活和转移。本综述探讨了关于某些 lncRNA 如何在 PI3K/Akt 信号通路中发挥促癌或抑癌作用的最新发现。某些 lncRNAs 可作为致癌因子或肿瘤抑制因子,使其成为潜在的诊断和预后标志物。以这些 lncRNA 为靶标可能会带来新的治疗策略。精准医疗和人工智能领域的不断发展有望推动 OSCC 诊断和治疗的进步,使患者护理更加个性化和有效。
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来源期刊
CiteScore
5.00
自引率
3.60%
发文量
405
审稿时长
24 days
期刊介绍: Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.
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