[Expert consensus on the clinical application of aromatase inhibitors to improve adolescent height].

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Abstract

Aromatase inhibitors have been widely used to improve height in the world and China. However, due to their off-label use and relatively short application time, there is a lack of consistent understanding and expert consensus on the indications, efficacy, and side effects of the drugs at home and abroad. Therefore, the Growth and Development and Gonadal Diseases Committee of Chinese Aging Well Association and the Adolescent Medicine and Health Professional Committee of the Chinese Medical Doctor Association organized 28 domestic experts in growth and development, based on the clinical evidence level classification and recommendation level of the Oxford University Evidence-Based Medicine Center to establish some preliminary recommendations on the efficacy, adverse reactions, precautions, dosage, and course of use of aromatase inhibitors in treating children with short stature and improving their year-end height. Combined with the Delphi method evaluation, 14 recommendations were finally formulated to standardized the clinical application of aromatase inhibitors in improving adolescent height.

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[关于临床应用芳香化酶抑制剂改善青少年身高的专家共识]。
在世界和中国,芳香化酶抑制剂已被广泛用于改善身高。但由于其标签外使用和应用时间较短,国内外对其适应症、疗效、副作用等缺乏一致的认识和专家共识。为此,中国老年保健协会生长发育与性腺疾病专业委员会和中国医师协会青少年医药卫生专业委员会组织了国内28位生长发育方面的专家,依据牛津大学循证医学中心的临床证据水平分类和推荐水平,对芳香化酶抑制剂治疗儿童矮身材、改善儿童年终身高的疗效、不良反应、注意事项、用量、疗程等方面提出了一些初步建议。结合德尔菲法评估,最终制定了14条建议,以规范芳香化酶抑制剂在改善青少年身高方面的临床应用。
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来源期刊
Zhonghua yi xue za zhi
Zhonghua yi xue za zhi Medicine-Medicine (all)
CiteScore
0.80
自引率
0.00%
发文量
400
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