Platelets at the intersection of inflammation and coagulation in the APC-mediated response to myocardial ischemia/reperfusion injury

IF 4.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY FASEB Journal Pub Date : 2024-08-14 DOI:10.1096/fj.202401128R

Lily Slotabec, Blaise Seale, Hao Wang, Changhong Wen, Fernanda Filho, Nadiyeh Rouhi, Michael I. Adenawoola, Ji Li

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Abstract

Thromboinflammation is a complex pathology associated with inflammation and coagulation. In cases of cardiovascular disease, in particular ischemia–reperfusion injury, thromboinflammation is a common complication. Increased understanding of thromboinflammation depends on an improved concept of the mechanisms of cells and proteins at the axis of coagulation and inflammation. Among these elements are activated protein C and platelets. This review summarizes the complex interactions of activated protein C and platelets regulating thromboinflammation in cardiovascular disease. By unraveling the pathways of platelets and APC in the inflammatory and coagulation cascades, this review summarizes the role of these vital mediators in the development and perpetuation of heart disease and the thromboinflammation-driven complications of cardiovascular disease. Furthermore, this review emphasizes the significance of the counteracting effects of platelets and APC and their combined role in disease states.

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在 APC 介导的心肌缺血/再灌注损伤反应中，血小板处于炎症和凝血的交汇点。

血栓炎是一种与炎症和凝血有关的复杂病理现象。在心血管疾病，特别是缺血再灌注损伤的病例中，血栓炎是一种常见的并发症。要加深对血栓炎症的了解，就必须提高对凝血和炎症轴心的细胞和蛋白质机制的认识。其中包括活化蛋白 C 和血小板。这篇综述总结了活化蛋白 C 和血小板在心血管疾病中调节血栓炎的复杂相互作用。通过揭示血小板和活化蛋白 C 在炎症和凝血级联中的作用途径，本综述总结了这些重要介质在心脏病的发展和延续以及由血栓炎症驱动的心血管疾病并发症中的作用。此外，本综述还强调了血小板和凝血活酶的抗衡作用及其在疾病状态中的综合作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

FASEB Journal 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

6243

审稿时长

3 months

期刊介绍： The FASEB Journal publishes international, transdisciplinary research covering all fields of biology at every level of organization: atomic, molecular, cell, tissue, organ, organismic and population. While the journal strives to include research that cuts across the biological sciences, it also considers submissions that lie within one field, but may have implications for other fields as well. The journal seeks to publish basic and translational research, but also welcomes reports of pre-clinical and early clinical research. In addition to research, review, and hypothesis submissions, The FASEB Journal also seeks perspectives, commentaries, book reviews, and similar content related to the life sciences in its Up Front section.