Clinicopathologic Correlation and Routine Immunostains Help Distinguish Congenital Disseminated Pyogenic Granuloma From Other Cutaneous Disseminated Vascular Proliferations of Infancy: Case Report and Literature Review.

IF 1.1 4区 医学 Q4 DERMATOLOGY American Journal of Dermatopathology Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI:10.1097/DAD.0000000000002830
Kristan Schiele, Veronica Voronina, Arthur Marka, Julianne Mann, Robert E LeBlanc
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Abstract

Abstract: The presence of multiple cutaneous vascular lesions in infancy can signal the possibility of visceral involvement. Dermatopathologists must appreciate how the differential diagnosis includes entities that have distinct therapeutic and prognostic implications. Fortunately, these rare entities can be distinguished histopathologically with the help of clinicopathologic correlation and immunohistochemistry. In this article, we discuss congenital disseminated pyogenic granuloma, multifocal infantile hemangioma, and multifocal lymphangioendotheliomatosis with thrombocytopenia. Subtle morphologic and immunophenotypic features permit their distinction, which in turn is important for identifying extracutaneous manifestations and effective treatments. We present a case of a 3-week-old infant with congenital disseminated pyogenic granuloma involving the skin and the liver whose lesions regressed without therapeutic intervention over 6 months of close follow-up. We review the literature on these rare, overlapping entities and present an approach to resolving the differential diagnosis.

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临床病理相关性和常规免疫印迹有助于区分先天性播散性化脓性肉芽肿和其他婴儿期皮肤播散性血管增生:病例报告和文献综述。
摘要:婴儿期出现多发性皮肤血管病变可能预示着内脏受累。皮肤病理学家必须了解鉴别诊断如何包括具有不同治疗和预后影响的实体。幸运的是,在临床病理相关性和免疫组化的帮助下,这些罕见的实体可以通过组织病理学加以区分。本文将讨论先天性播散性化脓性肉芽肿、多灶性婴儿血管瘤和伴血小板减少的多灶性淋巴管内皮细胞瘤病。微妙的形态学和免疫表型特征可以将它们区分开来,而这对于确定皮肤外表现和有效治疗也很重要。我们介绍了一例 3 周大婴儿先天性播散性化脓性肉芽肿病例,该病累及皮肤和肝脏,经过 6 个月的密切随访,病变在没有治疗干预的情况下消退。我们回顾了有关这些罕见、重叠实体的文献,并介绍了一种解决鉴别诊断的方法。
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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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