Neurocardiac Axis Physiology and Clinical Applications

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS IJC Heart and Vasculature Pub Date : 2024-08-14 DOI:10.1016/j.ijcha.2024.101488
Caroline Plott , Tarek Harb , Marios Arvanitis , Gary Gerstenblith , Roger Blumenthal , Thorsten Leucker
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Abstract

The neurocardiac axis constitutes the neuronal circuits between the arteries, heart, brain, and immune organs (including thymus, spleen, lymph nodes, and mucosal associated lymphoid tissue) that together form the cardiovascular brain circuit. This network allows the individual to maintain homeostasis in a variety of environmental situations. However, in dysfunctional states, such as exposure to environments with chronic stressors and sympathetic activation, this axis can also contribute to the development of atherosclerotic vascular disease as well as other cardiovascular pathologies and it is increasingly being recognized as an integral part of the pathogenesis of cardiovascular disease. This review article focuses on 1) the normal functioning of the neurocardiac axis; 2) pathophysiology of the neurocardiac axis; 3) clinical implications of this axis in hypertension, atherosclerotic disease, and heart failure with an update on treatments under investigation; and 4) quantification methods in research and clinical practice to measure components of the axis and future research areas.

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神经心轴生理学与临床应用
神经心脏轴由动脉、心脏、大脑和免疫器官(包括胸腺、脾脏、淋巴结和粘膜相关淋巴组织)之间的神经元回路组成,共同构成心血管脑回路。这一网络能让人在各种环境中保持平衡。然而,在功能失调的状态下,如暴露于慢性应激因素和交感神经激活的环境中,这一轴心也会导致动脉粥样硬化性血管疾病和其他心血管病变的发生,并且越来越多的人认识到它是心血管疾病发病机制中不可或缺的一部分。这篇综述文章的重点是:1)神经心血管轴的正常功能;2)神经心血管轴的病理生理学;3)该轴在高血压、动脉粥样硬化性疾病和心力衰竭中的临床意义,以及正在研究的最新治疗方法;4)研究和临床实践中测量该轴组成部分的量化方法以及未来的研究领域。
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来源期刊
IJC Heart and Vasculature
IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine
CiteScore
4.90
自引率
10.30%
发文量
216
审稿时长
56 days
期刊介绍: IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.
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