Factors that determine cell type–specific CTCF binding in health and disease

IF 3.7 2区 生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-08-13 DOI:10.1016/j.gde.2024.102244
Catherine Do , Jane A Skok
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Abstract

A number of factors contribute to cell type–specific CTCF chromatin binding, but how they act in concert to determine binding stability and functionality has not been fully elucidated. In this review, we tie together different layers of regulation to provide a holistic view of what is known. What emerges from these studies is a multifaceted system in which DNA sequence, DNA and chromatin accessibility, and cell type–specific transcription factors together contribute to CTCF binding profile and function. We discuss these findings in the light of disease settings in which changes in the chromatin landscape and transcriptional programming can disrupt CTCF’s binding profile and involvement in looping.

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决定健康和疾病中细胞类型特异性 CTCF 结合的因素
多种因素促成了细胞类型特异性的 CTCF 染色质结合,但这些因素如何协同作用以决定结合的稳定性和功能性尚未完全阐明。在这篇综述中,我们将不同层次的调控结合在一起,以提供一个对已知情况的整体看法。这些研究揭示了一个多层面的系统,在这个系统中,DNA 序列、DNA 和染色质可及性以及细胞类型特异性转录因子共同作用于 CTCF 的结合特征和功能。在疾病环境中,染色质景观和转录程序的变化会破坏 CTCF 的结合轮廓和在循环中的参与,我们将根据这些发现进行讨论。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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