Novel biocompatible pH-fluorescence responsive MOF nanocarriers for lung cancer treatment

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Inorganica Chimica Acta Pub Date : 2024-08-12 DOI:10.1016/j.ica.2024.122317

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Abstract

In this study, we synthesized two novel metal–organic frameworks [Cd(C₄H₄N₂)(C₁₂H₁₉P₃O₉)]n (1) and {Ca[Cd(H₂O)₃]₂(C₂₄H₁₅N₆O₆)₂}n (2) distinguished by exceptional fluorescence properties. Focusing on 1, we innovatively combined it with hydroxypropyl cellulose (HPC) to create a pH-responsive, fluorescence-guided nanocarrier system (HPC-1@DOX) for targeted delivery of doxorubicin (DOX) in cancer treatment. We thoroughly evaluated the loading and release efficiency of DOX under varied pH conditions, demonstrating sustained and controlled drug release characteristics in vitro, along with substantial drug-loading capacity. Notably, HPC-1@DOX exhibited pH-responsive behavior, releasing DOX preferentially at pH 6.8, indicative of targeted delivery to tumor and inflammatory sites while minimizing release at higher pH values. Moreover, we explored its biological impact, confirming HPC-1@DOX’s ability to up-regulate miR-493-3p expression in lung carcinoma cells, thereby inhibiting proliferation, reducing invasiveness, and inducing apoptosis. This multifunctional nanocarrier system represents a significant advancement towards targeted and effective cancer therapy.

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用于肺癌治疗的新型生物相容性 pH 荧光响应 MOF 纳米载体

在本研究中，我们合成了两种新型金属有机框架[Cd(C4H4N2)(C12H19P3O9)]n（1）和{Ca[Cd(H2O)3]2(C24H15N6O6)2}n（2），这两种框架具有优异的荧光特性。针对 1，我们创新性地将其与羟丙基纤维素（HPC）结合，创建了一种 pH 响应、荧光引导的纳米载体系统（HPC-1@DOX），用于在癌症治疗中靶向递送多柔比星（DOX）。我们对不同 pH 值条件下 DOX 的负载和释放效率进行了全面评估，结果表明该系统在体外具有持续、可控的药物释放特性，并具有很强的药物负载能力。值得注意的是，HPC-1@DOX 表现出了 pH 值响应行为，在 pH 值为 6.8 时优先释放 DOX，这表明它能定向地向肿瘤和炎症部位释放药物，同时在较高的 pH 值下释放量最小。此外，我们还探究了它的生物学影响，证实 HPC-1@DOX 能够上调肺癌细胞中 miR-493-3p 的表达，从而抑制增殖、降低侵袭性并诱导细胞凋亡。这种多功能纳米载体系统是癌症靶向有效治疗的一大进步。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.