Diagnostic properties of miR-146a-5p from liquid biopsies in prostate cancer: A meta-analysis

IF 2.9 4区医学 Q2 PATHOLOGY Pathology, research and practice Pub Date : 2024-08-13 DOI:10.1016/j.prp.2024.155522

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Abstract

Background

Several studies on biomarker properties of microRNAs from liquid biopsy in prostate cancer (PCa) identified miR-146a-5p as a potential novel diagnostic marker. However, other studies with the same or similar topic failed to confirm the supposed discriminatory ability of miR-146a-5p, for which reason we aimed at elucidating the potential biomarker role of circulatory/urinary miR-146a-5p in PCa by conducting a qualitative and quantitative data synthesis.

Methods

Eligible articles were identified by searching PubMed, Scopus and Web of Science databases. Open MetaAnalyst software was used for pooling data on sensitivity, specificity, likelihood ratio and diagnostic odds ratio (OR) of miR-146a-5p.

Results

A total of 15 articles were eligible for qualitative data synthesis, while the results from 13 studies with 2080 participants were included in the meta-analysis. The established between-study heterogeneity was high, while the expression of hsa-miR-146a was associated with a diagnostic OR of 3.544 (P < 0.001; 95 %CI 2.186–5.747). Pooled sensitivity was found to be lower than 70 % (0.655, 95 %CI 0.573–0.729, P < 0.001), while the obtained value for specificity was 65 % (95 %CI 0.583–0.709, P < 0.001). Segregating studies according to ethnicity, sample type or the type of controls did not result in significantly higher sensitivity and specificity in subgroups, compared to the overall pooled data.

Conclusions

The resulting pooled sensitivity, specificity and diagnostic OR do not qualify miR-146a-5p for a reliable diagnostic biomarker of PCa.

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前列腺癌液体活检中 miR-146a-5p 的诊断特性：荟萃分析

背景多项关于前列腺癌（PCa）液体活检中微小RNA生物标志物特性的研究发现，miR-146a-5p是一种潜在的新型诊断标志物。然而，其他相同或相似主题的研究未能证实 miR-146a-5p 的所谓鉴别能力，因此我们旨在通过定性和定量数据综合，阐明循环/泌尿 miR-146a-5p 在 PCa 中的潜在生物标记作用。结果共有 15 篇文章符合定性数据综合的条件，13 项研究的 2080 名参与者的结果被纳入荟萃分析。已确定的研究间异质性很高，而 hsa-miR-146a 的表达与 3.544 的诊断 OR 有关（P < 0.001; 95 %CI 2.186-5.747）。汇总灵敏度低于 70%（0.655，95 %CI 0.573-0.729，P <0.001），而特异度为 65%（95 %CI 0.583-0.709，P <0.001）。与总体汇总数据相比，根据种族、样本类型或对照类型对研究进行分类并不能使亚组的灵敏度和特异性显著提高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.