Pavle Randjelović, Niko Radulović, Nikola Stojanović, Ivan Ilić
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引用次数: 0
Abstract
Selenium (Se) is an essential trace element. Depending on concentration, Se can manifest both beneficial and harmful effects on the cell and can have both oxidative and antioxidant effects. Because the therapeutic index for Se is very narrow and it can depend on the form of Se used, we aimed to investigate the potential safety and side effects of inorganic Se on kidney function and structure in rats. After 8 days of treatment, no detectable signs of microscopic changes or oxidative stress in kidney tissue were observed. We detected a moderate increase in urea and creatinine levels in the blood as a sign of a slight decrease in kidney function. The most notable changes in our study were morphometric alterations in proximal tubules and glomeruli, both of which were considerably enlarged. The short-term application of inorganic Se to rats in a supratherapeutic dose induced mild functional and ultrastructural changes in the kidneys. The dose of inorganic Se used could be considered relatively safe for short-term application in situations where Se could be beneficial to the organism, such as the usage of known nephrotoxicants or high levels of oxidative stress in the body.
硒(Se)是一种人体必需的微量元素。根据浓度的不同,硒对细胞既有益处也有害处,既有氧化作用也有抗氧化作用。由于 Se 的治疗指数非常窄,而且可能取决于所使用的 Se 形态,因此我们旨在研究无机 Se 对大鼠肾功能和肾结构的潜在安全性和副作用。经过 8 天的治疗后,在肾脏组织中未发现可检测到的微观变化或氧化应激迹象。我们检测到血液中尿素和肌酐水平略有上升,这表明肾功能略有下降。在我们的研究中,最显著的变化是近端肾小管和肾小球的形态改变,两者都明显增大。对大鼠短期施用超治疗剂量的无机硒会引起肾脏轻微的功能和超微结构变化。所使用的无机硒剂量在短期应用中相对安全,因为硒可能对机体有益,如使用已知的肾毒性药物或体内氧化应激水平较高。
期刊介绍:
Acta Veterinaria Hungarica publishes original research papers presenting new scientific results of international interest, and to a limited extent also review articles and clinical case reports, on veterinary physiology (physiological chemistry and metabolism), veterinary microbiology (bacteriology, virology, immunology, molecular biology), on the infectious diseases of domestic animals, on veterinary parasitology, pathology, clinical veterinary science and reproduction.