Intricate response dynamics enhances stimulus discrimination in the resource-limited C. elegans chemosensory system.

IF 4.4 1区 生物学 Q1 BIOLOGY BMC Biology Pub Date : 2024-08-15 DOI:10.1186/s12915-024-01977-z
Eduard Bokman, Christian O Pritz, Rotem Ruach, Eyal Itskovits, Hadar Sharvit, Alon Zaslaver
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Abstract

Background: Sensory systems evolved intricate designs to accurately encode perplexing environments. However, this encoding task may become particularly challenging for animals harboring a small number of sensory neurons. Here, we studied how the compact resource-limited chemosensory system of Caenorhabditis elegans uniquely encodes a range of chemical stimuli.

Results: We find that each stimulus is encoded using a small and unique subset of neurons, where only a portion of the encoding neurons sense the stimulus directly, and the rest are recruited via inter-neuronal communication. Furthermore, while most neurons show stereotypical response dynamics, some neurons exhibit versatile dynamics that are either stimulus specific or network-activity dependent. Notably, it is the collective dynamics of all responding neurons which provides valuable information that ultimately enhances stimulus identification, particularly when required to discriminate between closely related stimuli.

Conclusions: Together, these findings demonstrate how a compact and resource-limited chemosensory system can efficiently encode and discriminate a diverse range of chemical stimuli.

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错综复杂的反应动态增强了资源有限的秀丽隐杆线虫化学感觉系统对刺激的辨别能力。
背景:感官系统进化出了复杂的设计,以准确地编码令人困惑的环境。然而,对于感官神经元数量较少的动物来说,这种编码任务可能会变得特别具有挑战性。在这里,我们研究了草履虫资源有限的紧凑型化学感觉系统如何对一系列化学刺激进行独特编码:结果:我们发现,每种刺激都是通过一小部分独特的神经元子集进行编码的,其中只有一部分编码神经元能直接感知刺激,其余神经元则通过神经元间的通信被调用。此外,虽然大多数神经元表现出刻板的反应动态,但也有一些神经元表现出多变的动态,这些动态或与刺激有关,或与网络活动有关。值得注意的是,正是所有反应神经元的集体动态提供了有价值的信息,最终增强了刺激识别能力,尤其是在需要区分密切相关的刺激时:这些发现共同证明了一个结构紧凑、资源有限的化学感觉系统是如何有效地编码和辨别各种化学刺激的。
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来源期刊
BMC Biology
BMC Biology 生物-生物学
CiteScore
7.80
自引率
1.90%
发文量
260
审稿时长
3 months
期刊介绍: BMC Biology is a broad scope journal covering all areas of biology. Our content includes research articles, new methods and tools. BMC Biology also publishes reviews, Q&A, and commentaries.
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