The causal relationships of granulocytes and melanoma skin cancer: A univariable and multivariable Mendelian randomization study.

IF 2 4区医学 Q3 DERMATOLOGY Skin Research and Technology Pub Date : 2024-08-01 DOI:10.1111/srt.70007

Zhang Rui-Chang, Peng Hui-Zi, Zhou Lin

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Abstract

Background: Increasing evidence has revealed that granulocyte has a critical role in tumorigenesis and progression. In this study, Mendelian randomization (MR) analysis was utilized for estimating the causal association between neutrophil percentage and melanoma skin cancer, eosinophil percentage and melanoma skin cancer, basophil percentage and melanoma skin cancer, respectively.

Methods: The Genome-Wide Association Study (GWAS) ids for melanoma skin cancer, neutrophil percentage, eosinophil percentage and basophil percentage were derived from Integrative Epidemiology Unit (IEU) Open GWAS database. The univariable MR (UVMR) analysis was conducted to estimate the risk using MR-Egger, weighted median, inverse variance weighted (IVW). In addition, sensitivity analysis was conducted to assess the reliability of UVMR results. Finally, the multivariable MR (MVMR) analysis was performed to investigate causality between neutrophil percentage and eosinophil percentage in the presence of both and melanoma skin cancer.

Results: The UVMR indicated that neutrophil percentage and eosinophil percentage were significantly and causally related to melanoma skin cancer, with neutrophil percentage [p = 0.025, odds ratio (OR) = 1.002] as a risk factor and eosinophil percentage (p = 7.04E-06, OR = 0.997) as a protective factor. Moreover, MVMR analysis indicated eosinophil percentage remained the protective factor (p = 0.003, OR = 0.998), while the causality of neutrophil percentage and melanoma skin cancer became insignificant (p > 0.05).

Conclusion: The causal relationships of neutrophil percentage and melanoma skin cancer, eosinophil percentage and melanoma skin cancer were shown by this study, which provided a reference for subsequent research and treatment related to melanoma skin cancer.

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粒细胞与黑色素瘤皮肤癌的因果关系：单变量和多变量孟德尔随机研究

背景：越来越多的证据表明，粒细胞在肿瘤发生和发展过程中起着至关重要的作用。本研究利用孟德尔随机分析法（MR）分别估计了中性粒细胞百分比与黑色素瘤皮肤癌、嗜酸性粒细胞百分比与黑色素瘤皮肤癌、嗜碱性粒细胞百分比与黑色素瘤皮肤癌之间的因果关系：方法：黑色素瘤皮肤癌、中性粒细胞百分比、嗜酸性粒细胞百分比和嗜碱性粒细胞百分比的全基因组关联研究（GWAS）ID来自Integrative Epidemiology Unit (IEU) Open GWAS数据库。采用 MR-Egger、加权中位数、逆方差加权（IVW）进行了单变量 MR（UVMR）分析，以估计风险。此外，还进行了敏感性分析，以评估 UVMR 结果的可靠性。最后，进行了多变量 MR（MVMR）分析，以研究中性粒细胞百分比和嗜酸性粒细胞百分比与黑色素瘤皮肤癌之间的因果关系：UVMR表明，中性粒细胞百分比和嗜酸性粒细胞百分比与黑色素瘤皮肤癌有显著的因果关系，其中中性粒细胞百分比[p = 0.025，比值比（OR） = 1.002]是一个危险因素，而嗜酸性粒细胞百分比（p = 7.04E-06，OR = 0.997）是一个保护因素。此外，MVMR 分析表明，嗜酸性粒细胞百分比仍是保护因素（p = 0.003，OR = 0.998），而中性粒细胞百分比与黑色素瘤皮肤癌的因果关系变得不显著（p > 0.05）：本研究显示了中性粒细胞百分比与黑色素瘤皮肤癌、嗜酸性粒细胞百分比与黑色素瘤皮肤癌的因果关系，为后续黑色素瘤皮肤癌的相关研究和治疗提供了参考。

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来源期刊

Skin Research and Technology 医学-皮肤病学

CiteScore

3.30

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.