Effect of hydrocolloid-nitric oxide wound dressings on wound healing in dogs.

IF 1.3 2区农林科学 Q2 VETERINARY SCIENCES Veterinary Surgery Pub Date : 2024-08-16 DOI:10.1111/vsu.14149

Jenniffer M Rodriguez-Diaz, Mandy L Wallace, Sarah A Emond, Danielle McNabney, Katie M Hodges, Elizabeth W Howerth

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Abstract

Objective: To determine the rates of wound healing in surgically created wounds between nitric oxide releasing wound dressings and control wound dressings.

Study design: Prospective, controlled, randomized experimental study.

Animals: Purpose-bred, adult, male Beagles (n = 6).

Methods: Four 2 × 2 cm wounds were surgically created on the trunk of each dog with each wound randomized to treatment with a nitric oxide wound pad (NP), nitric oxide wound gel (NG), plain hydrocolloid wound dressing (HC), or Telfa pad (T). Wound images were taken daily for 8 days then every other day until day 21 with images masked and randomized for evaluation. Total wound area, contraction percentage, and days until granulation were calculated.

Results: Time to first appearance of granulation tissue was significantly shorter for NP (3.2 days) than for NG (4 days; p = .023), HC (4.5 days; p = .001), and T (5.2 days; p < .0001). There were significant differences in total wound area and contraction percentage between sites and treatments (p < .001). Total wound area for NG was lower than treatment T (0.7 ± 0.1 cm³; p < .001), HC (0.9 ± 0.1 cm³, p < .001), and NP (0.6 ± 0.1 cm³, p < .001).

Conclusion: Use of a nitric oxide wound dressing resulted in faster wound healing as evidenced by lower total wound area and higher contraction in the NG group and faster time to granulation tissue development in the NP group.

Clinical significance: Nitric oxide wound dressings are innovative and inexpensive products that can significantly decrease the amount of time and cost necessary for open or second intention wound resolution in dogs.

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水胶体一氧化氮伤口敷料对狗伤口愈合的影响。

研究目的确定释放一氧化氮的伤口敷料与对照伤口敷料在手术伤口愈合率上的差异：前瞻性、对照、随机实验研究：动物：专门饲养的成年雄性比格犬（n = 6）：方法：在每只狗的躯干上用手术造成 4 个 2 × 2 厘米的伤口，每个伤口随机使用一氧化氮伤口垫 (NP)、一氧化氮伤口凝胶 (NG)、普通水胶体伤口敷料 (HC) 或特尔发伤口垫 (T)。每天拍摄伤口图像，连续拍摄 8 天，然后隔天拍摄一次，直到第 21 天，并对图像进行遮蔽和随机评估。计算伤口总面积、收缩百分比和肉芽形成前的天数：结果：NP（3.2 天）首次出现肉芽组织的时间明显短于 NG（4 天；P = 0.023）、HC（4.5 天；P = 0.001）和 T（5.2 天；P 3；P 3；P 3，P 3，P 结论：使用一氧化氮伤口敷料可加快伤口愈合，这体现在 NG 组伤口总面积更小、收缩率更高，而 NP 组肉芽组织生长时间更快：一氧化氮伤口敷料是一种创新型廉价产品，可显著减少犬开放性或第二意图伤口愈合所需的时间和成本。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Surgery 农林科学-兽医学

CiteScore

3.40

自引率

22.20%

发文量

162

审稿时长

8-16 weeks

期刊介绍： Veterinary Surgery, the official publication of the American College of Veterinary Surgeons and European College of Veterinary Surgeons, is a source of up-to-date coverage of surgical and anesthetic management of animals, addressing significant problems in veterinary surgery with relevant case histories and observations. It contains original, peer-reviewed articles that cover developments in veterinary surgery, and presents the most current review of the field, with timely articles on surgical techniques, diagnostic aims, care of infections, and advances in knowledge of metabolism as it affects the surgical patient. The journal places new developments in perspective, encompassing new concepts and peer commentary to help better understand and evaluate the surgical patient.