Swathi Kaliki, Vijitha S Vempuluru, Komal Rajendra Bakal, Samten Dorji, Vishakha Tanna, Charlotte N Shields, Samuel J Fallon, Vishal Raval, Alia Ahmad, Asma Mushtaq, Mahvish Hussain, Yacoub A Yousef, Mona Mohammad, Soma Rani Roy, Fahmida Huque, Ushakova Tatiana, Serov Yuri, Polyakov Vladimir, Sandro Casavilca Zambrano, Sandra Alarcón-León, Cinthya Valdiviezo-Zapata, Maria Vargas-Martorellet, Cynthia Gutierrez-Chira, Mario Buitrago, Joana Sánchez Ortiz, Rosdali Diaz-Coronado, Devjyoti Tripathy, Suryasnata Rath, Gaurav Patil, Jesse L Berry, Sarah Pike, Brianne Brown, Mika Tanabe, Shahar Frenkel, Maya Eiger-Moscovich, Jacob Pe'er, Carol L Shields, Ralph C Eagle, Andrea Laiton, Ana Maria Velasco, Katherine Vega, Joseph DeSimone, Kavya Madhuri Bejjanki, Anasua Ganguly Kapoor, Anusha Venkataraman, Victoria Bryant, M Ashwin Reddy, Mandeep S Sagoo, G Baker Hubbard, Corrina P Azarcon, Thomas A Olson, Hans Grossniklaus, Olivia Rolfe, Sandra E Staffieri, Roderick O'Day, Anu A Mathew, James E Elder, John D McKenzie, Ido Didi Fabian, Rachel Shemesh, Vicktoria Vishnevskia-Dai, Mohammed Hasnat Ali, Saumya Jakati, Dilip K Mishra, Vijay Anand Reddy Palkonda
{"title":"High-Risk Histopathological Features of Retinoblastoma following Primary Enucleation: A Global Study of 1426 Patients from 5 Continents.","authors":"Swathi Kaliki, Vijitha S Vempuluru, Komal Rajendra Bakal, Samten Dorji, Vishakha Tanna, Charlotte N Shields, Samuel J Fallon, Vishal Raval, Alia Ahmad, Asma Mushtaq, Mahvish Hussain, Yacoub A Yousef, Mona Mohammad, Soma Rani Roy, Fahmida Huque, Ushakova Tatiana, Serov Yuri, Polyakov Vladimir, Sandro Casavilca Zambrano, Sandra Alarcón-León, Cinthya Valdiviezo-Zapata, Maria Vargas-Martorellet, Cynthia Gutierrez-Chira, Mario Buitrago, Joana Sánchez Ortiz, Rosdali Diaz-Coronado, Devjyoti Tripathy, Suryasnata Rath, Gaurav Patil, Jesse L Berry, Sarah Pike, Brianne Brown, Mika Tanabe, Shahar Frenkel, Maya Eiger-Moscovich, Jacob Pe'er, Carol L Shields, Ralph C Eagle, Andrea Laiton, Ana Maria Velasco, Katherine Vega, Joseph DeSimone, Kavya Madhuri Bejjanki, Anasua Ganguly Kapoor, Anusha Venkataraman, Victoria Bryant, M Ashwin Reddy, Mandeep S Sagoo, G Baker Hubbard, Corrina P Azarcon, Thomas A Olson, Hans Grossniklaus, Olivia Rolfe, Sandra E Staffieri, Roderick O'Day, Anu A Mathew, James E Elder, John D McKenzie, Ido Didi Fabian, Rachel Shemesh, Vicktoria Vishnevskia-Dai, Mohammed Hasnat Ali, Saumya Jakati, Dilip K Mishra, Vijay Anand Reddy Palkonda","doi":"10.1097/IAE.0000000000004250","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate high-risk histopathological features (HRHF) following primary enucleation of eyes with retinoblastoma (RB) and assess the patient outcomes across continents.</p><p><strong>Methods: </strong>Retrospective study of 1426 primarily enucleated RB eyes from five continents.</p><p><strong>Results: </strong>Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA). Based on the continent (AS vs. AUS vs. EUR vs. NA vs. SA), the histopathology features included massive choroidal invasion (31% vs. 7% vs. 13% vs. 19% vs. 27%, p=0.001), post-laminar optic nerve invasion (27% vs. 0% vs. 16% vs. 21% vs. 19%, p=0.0006), scleral infiltration (5% vs. 0% vs. 4% vs. 2% vs. 7%, p=0.13), and microscopic extrascleral infiltration (4% vs. 0% vs. <1% vs. <1% vs. 4%, p=0.68). Adjuvant chemotherapy with/without orbital radiotherapy was given in 761 (53%) patients. Based on Kaplan-Meier estimates in different continents (AS vs. AUS vs. EUR vs. NA vs. SA), the 6-year risk of orbital tumor recurrence was 5% vs. 2% vs. 0% vs. 0% vs. 12% (p<0.001), systemic metastasis was reported in 8% vs. 5% vs. 2% vs. 0% vs. 13% (p=0.001), and death in 10% vs. 3% vs. 2% vs. 0% vs. 11% (p<0.001) patients.</p><p><strong>Conclusion: </strong>There is a wide variation in the infiltrative histopathology features of RB across continents, resulting in variable outcomes. SA and AS had a higher risk of orbital tumor recurrence, systemic metastasis, and death compared to AUS, EUR, and NA.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Retina-The Journal of Retinal and Vitreous Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/IAE.0000000000004250","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: To evaluate high-risk histopathological features (HRHF) following primary enucleation of eyes with retinoblastoma (RB) and assess the patient outcomes across continents.
Methods: Retrospective study of 1426 primarily enucleated RB eyes from five continents.
Results: Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA). Based on the continent (AS vs. AUS vs. EUR vs. NA vs. SA), the histopathology features included massive choroidal invasion (31% vs. 7% vs. 13% vs. 19% vs. 27%, p=0.001), post-laminar optic nerve invasion (27% vs. 0% vs. 16% vs. 21% vs. 19%, p=0.0006), scleral infiltration (5% vs. 0% vs. 4% vs. 2% vs. 7%, p=0.13), and microscopic extrascleral infiltration (4% vs. 0% vs. <1% vs. <1% vs. 4%, p=0.68). Adjuvant chemotherapy with/without orbital radiotherapy was given in 761 (53%) patients. Based on Kaplan-Meier estimates in different continents (AS vs. AUS vs. EUR vs. NA vs. SA), the 6-year risk of orbital tumor recurrence was 5% vs. 2% vs. 0% vs. 0% vs. 12% (p<0.001), systemic metastasis was reported in 8% vs. 5% vs. 2% vs. 0% vs. 13% (p=0.001), and death in 10% vs. 3% vs. 2% vs. 0% vs. 11% (p<0.001) patients.
Conclusion: There is a wide variation in the infiltrative histopathology features of RB across continents, resulting in variable outcomes. SA and AS had a higher risk of orbital tumor recurrence, systemic metastasis, and death compared to AUS, EUR, and NA.
目的：评估视网膜母细胞瘤（RB）患者初次去核术后的高危组织病理学特征（HRHF），并评估各大洲患者的预后：方法：对来自五大洲的1426只主要接受去核手术的RB眼球进行回顾性研究：其中，923 只（65%）来自亚洲（AS），27 只（2%）来自澳大利亚（AUS），120 只（8%）来自欧洲（EUR），162 只（11%）来自北美洲（NA），194 只（14%）来自南美洲（SA）。根据大陆（澳大利亚 vs. 澳大利亚 vs. 欧洲 vs. 北美 vs. 南美），组织病理学特征包括大面积脉络膜侵犯（31% vs. 7% vs. 13% vs. 19% vs. 27%，P=0.001）、层状视神经后侵犯（27% vs. 0% vs. 16% vs. 27%，P=0.001）、视神经后侵犯（27% vs. 0% vs. 16% vs. 27%，P=0.001）。0% vs. 16% vs. 21% vs. 19%，p=0.0006）、巩膜浸润（5% vs. 0% vs. 4% vs. 2% vs. 7%，p=0.13）和显微镜下巩膜外浸润（4% vs. 0% vs. 27%，p=0.001）：RB的浸润组织病理学特征在各大洲之间存在很大差异，导致了不同的结果。与澳大利亚、欧洲和北美洲相比，南澳大利亚州和澳大利亚州的眼眶肿瘤复发、全身转移和死亡风险更高。
期刊介绍：
RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice.
In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color.
Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.
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