High rates of mood disorders in patients with chronic idiopathic eosinopenia

IF 3.7 Q2 IMMUNOLOGY Brain, behavior, & immunity - health Pub Date : 2024-08-12 DOI:10.1016/j.bbih.2024.100847

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Abstract

Background

Mood disorders (MD) are multifactorial disorders. Identifying new biomarkers for the early diagnosis of MD and predicting response to treatment is currently a significant research topic. Both eosinopenia and MD are associated with increased activity of the hypothalamic-pituitary-adrenal axis. The present study, therefore, used a clear definition of chronic idiopathic eosinopenia (CIE) to determine the rate of MD in a large cohort of individuals with CIE.

Methods

This retrospective population-based, case-control study uses data of seven consecutive years from the database of Leumit Health Services (LHS) - a nationwide health maintenance organization in Israel.

Results

Participants were 13928 LHS members with CIE and 27858 negative controls. The CIE group exhibited significantly higher rates of MD than the control group throughout the whole study period, except for atypical depressive disorder at baseline.

Conclusions

CIE might be associated with a higher prevalence of MD. Further basic research should elucidate the pathophysiologic mechanisms linking CIE and MD.

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慢性特发性粒细胞减少症患者的情绪障碍发生率较高

背景情绪障碍（MD）是一种多因素疾病。为早期诊断情绪失调症和预测治疗反应确定新的生物标志物是目前的一个重要研究课题。粒细胞减少症和情绪失调症都与下丘脑-垂体-肾上腺轴活动增加有关。因此，本研究使用了慢性特发性卵磷脂减少症（CIE）的明确定义，以确定CIE患者大样本中的MD发病率。方法这项基于人群的病例对照回顾性研究使用了以色列全国性健康维护组织Leumit Health Services（LHS）数据库中连续七年的数据。在整个研究期间，除了基线时的非典型抑郁障碍外，CIE 组的 MD 患病率明显高于对照组。进一步的基础研究应阐明CIE与MD之间的病理生理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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