New paradigms to break barriers in early cancer detection for improved prognosis and treatment outcomes

IF 3.2 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of Gene Medicine Pub Date : 2024-08-17 DOI:10.1002/jgm.3730
Irfan Ahmad, Saade Abdalkareem Jasim, M. K. Sharma, Renuka Jyothi S, Ahmed Hjazi, Jaafaru Sani Mohammed, Aashna Sinha, Ahmed Hussein Zwamel, Hamza Fadhel Hamzah, Bahira Abdulrazzaq Mohammed
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Abstract

The uncontrolled growth and spread of cancerous cells beyond their usual boundaries into surrounding tissues characterizes cancer. In developed countries, cancer is the leading cause of death, while in underdeveloped nations, it ranks second. Using existing cancer diagnostic tools has increased early detection rates, which is crucial for effective cancer treatment. In recent decades, there has been significant progress in cancer-specific survival rates owing to advances in cancer detection and treatment. The ability to accurately identify precursor lesions is a crucial aspect of effective cancer screening programs, as it enables early treatment initiation, leading to lower long-term incidence of invasive cancer and improved overall prognosis. However, these diagnostic methods have limitations, such as high costs and technical challenges, which can make accurate diagnosis of certain deep-seated tumors difficult. To achieve accurate cancer diagnosis and prognosis, it is essential to continue developing cutting-edge technologies in molecular biology and cancer imaging.

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打破早期癌症检测障碍,改善预后和治疗效果的新模式
癌细胞不受控制地生长并向周围组织扩散,这就是癌症的特征。在发达国家,癌症是导致死亡的主要原因,而在不发达国家,癌症则位居第二。利用现有的癌症诊断工具提高了早期发现率,这对有效治疗癌症至关重要。近几十年来,由于癌症检测和治疗的进步,癌症患者的生存率有了显著提高。准确识别前驱病变的能力是有效癌症筛查计划的一个重要方面,因为它能使治疗尽早开始,从而降低浸润性癌症的长期发病率并改善总体预后。然而,这些诊断方法都有其局限性,例如成本高昂和技术难度大,因此很难准确诊断某些深部肿瘤。要实现准确的癌症诊断和预后,必须继续开发分子生物学和癌症成像方面的尖端技术。
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来源期刊
Journal of Gene Medicine
Journal of Gene Medicine 医学-生物工程与应用微生物
CiteScore
6.40
自引率
0.00%
发文量
80
审稿时长
6-12 weeks
期刊介绍: The aims and scope of The Journal of Gene Medicine include cutting-edge science of gene transfer and its applications in gene and cell therapy, genome editing with precision nucleases, epigenetic modifications of host genome by small molecules, siRNA, microRNA and other noncoding RNAs as therapeutic gene-modulating agents or targets, biomarkers for precision medicine, and gene-based prognostic/diagnostic studies. Key areas of interest are the design of novel synthetic and viral vectors, novel therapeutic nucleic acids such as mRNA, modified microRNAs and siRNAs, antagomirs, aptamers, antisense and exon-skipping agents, refined genome editing tools using nucleic acid /protein combinations, physically or biologically targeted delivery and gene modulation, ex vivo or in vivo pharmacological studies including animal models, and human clinical trials. Papers presenting research into the mechanisms underlying transfer and action of gene medicines, the application of the new technologies for stem cell modification or nucleic acid based vaccines, the identification of new genetic or epigenetic variations as biomarkers to direct precision medicine, and the preclinical/clinical development of gene/expression signatures indicative of diagnosis or predictive of prognosis are also encouraged.
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