Role of osteokines in atherosclerosis

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell Biochemistry and Function Pub Date : 2024-08-18 DOI:10.1002/cbf.4107

Yi-Fan Liu, Yuan Tian, Xiao-Fang Chen, Chi Zhang, Liang Huang

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Abstract

Despite their diverse physiologies and roles, the heart, skeletal muscles, and smooth muscles all derive from a common embryonic source as bones. Moreover, bone tissue, skeletal and smooth muscles, and the heart share conserved signaling pathways. The maintenance of skeletal health is precisely regulated by osteocytes, osteoblasts, and osteoclasts through coordinated secretion of bone-derived factors known as osteokines. Increasing evidence suggests the involvement of osteokines in regulating atherosclerotic vascular disease. Therefore, this review aims to examine the evidence for the role of osteokines in atherosclerosis development and progression comprehensively. Specifically discussed are extensively studied osteokines in atherosclerosis such as osteocalcin, osteopontin, osteoprotegerin, and fibroblast growth factor 23. Additionally, we highlighted the effects of exercise on modulating these key regulators derived from bone tissue metabolism. We believe that gaining an enhanced understanding of how osteocalcin contributes to the process of atherosclerosis will enable us to develop targeted and comprehensive therapeutic strategies against diseases associated with its progression.

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骨激酶在动脉粥样硬化中的作用

尽管心脏、骨骼肌和平滑肌的生理结构和作用各不相同，但它们都源自骨骼这一共同的胚胎来源。此外，骨组织、骨骼肌、平滑肌和心脏共享保守的信号通路。骨骼健康的维持是由骨细胞、成骨细胞和破骨细胞通过协调分泌骨源性因子（即骨激素）来精确调控的。越来越多的证据表明，骨生成素参与了动脉粥样硬化性血管疾病的调控。因此，本综述旨在全面研究骨促性因子在动脉粥样硬化发生和发展过程中发挥作用的证据。具体讨论了在动脉粥样硬化中被广泛研究的骨调理因子，如骨钙素、骨通蛋白、骨保护蛋白和成纤维细胞生长因子 23。此外，我们还强调了运动对调节这些来自骨组织代谢的关键调节因子的影响。我们相信，进一步了解骨钙素是如何促进动脉粥样硬化过程的，将有助于我们针对与动脉粥样硬化进展相关的疾病制定有针对性的综合治疗策略。

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.