Efficacy of ozone therapy for oral mucosa wound healing: a systematic review and meta-analysis.

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Clinical Oral Investigations Pub Date : 2024-08-17 DOI:10.1007/s00784-024-05873-2

Deisi Romitti Maglia, Bruna do Amaral Ferreira Souza, Fernanda Visioli

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Abstract

Objectives: To conduct a systematic review and meta-analysis to assess the effectiveness of ozone therapy in oral ulcers healing when compared to placebo or active treatments.

Materials and methods: The search was carried out using PubMed, EMBASE, Scopus, and Lilacs databases. Clinical trials involving human participants were included. The Risk Ratio (RR) and the standardized mean difference (SMD) with 95%CI (confidence interval) were calculated. The ROBINS-I (risk of bias in non-randomized studies of interventions) and RoB2 (risk of bias tool for randomized trials) assessment tool was used to detect bias.

Results: After the selection process, 12 studies were included. The meta-analysis showed that ozone therapy helps to reduce the size of the traumatic and autoimmune ulcers (RR=-0.44; 95% CI -0.71,-0.17; I²=0%) in comparison to placebo. Regarding pain reduction, ozone was superior to placebo (RR = 1.29, 95% CI -1.6 to -0.95); I²=0%), and equivalent to topical corticosteroid and laser photobiomodulation (RR = 0.26, 95% CI -0.27,0.78, p = 0.34).

Conclusion: Ozone therapy is an alternative for accelerating healing and reducing pain for both traumatic and autoimmune ulcers. However, the quality of evidence is limited.

Clinical relevance: Oral ulcerations are usually painful and impact quality of life requiring different approaches to boost wound healing and reduce symptoms. For this purpose, ozone therapy is a promising strategy.

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臭氧疗法对口腔黏膜伤口愈合的疗效：系统回顾和荟萃分析。

目的：进行系统综述和荟萃分析，评估臭氧疗法与安慰剂或活性疗法相比对口腔溃疡愈合的效果：进行系统回顾和荟萃分析，评估臭氧疗法与安慰剂或积极疗法相比对口腔溃疡愈合的有效性：使用 PubMed、EMBASE、Scopus 和 Lilacs 数据库进行检索。纳入了涉及人类参与者的临床试验。计算了风险比（RR）和标准化平均差异（SMD）及 95%CI（置信区间）。ROBINS-I（非随机干预研究的偏倚风险）和RoB2（随机试验的偏倚风险工具）评估工具用于检测偏倚：经过筛选，共纳入了 12 项研究。荟萃分析表明，与安慰剂相比，臭氧疗法有助于缩小创伤性和自身免疫性溃疡的面积（RR=-0.44；95% CI -0.71,-0.17；I2=0%）。在减轻疼痛方面，臭氧优于安慰剂（RR=1.29，95% CI -1.6 至 -0.95）；I2=0%），与外用皮质类固醇和激光光生物调节疗法相当（RR=0.26，95% CI -0.27,0.78，P=0.34）：结论：臭氧疗法是加速创伤性和自身免疫性溃疡愈合和减轻疼痛的替代疗法。结论：臭氧疗法是加速创伤性和自身免疫性溃疡愈合和减轻疼痛的替代疗法，但证据质量有限：口腔溃疡通常会带来疼痛，影响生活质量，需要采用不同的方法来促进伤口愈合和减轻症状。为此，臭氧疗法是一种很有前景的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.