Study of electrocardiographic corrected QT interval and QT dispersion abnormalities, erythrocyte sedimentation rate, serum uric acid in patients with systemic lupus erythematosus.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY Lupus Pub Date : 2024-10-01 Epub Date: 2024-08-18 DOI:10.1177/09612033241274599
Shinde Vikrant Vijaykumar, Gopikrishna G, Dhruva Nandi, J S Kumar
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Abstract

Introduction: Systemic Lupus Erythematosus (SLE) is an autoimmune disease having a variety of clinical symptoms because of multiple organs being affected at once or progressively over time. Cardiovascular system (CVS) involvement is the third most frequent cause of death in SLE, among other factors. The prognosis can be determined by looking at QT interval measurements, which have shown an elevated risk of mortality from cardiovascular causes.

Methods: A case-control study was conducted on 80 patients (40 SLE patients and 40 controls) for a duration of 16 months. SLE patients and controls were identified from the general medicine and rheumatology outpatient department (OPD) based on the inclusion criteria. A thorough clinical examination was performed after obtaining a detailed clinical history. Baseline blood tests were then performed on the SLE patients and ECG was taken from both cases and controls. The serum uric acid level was measured using an automated analyzer, and the ESR was computed using Westergren's Method. The corrected QT interval (QTc) was estimated using Bazett's method. All the collected data were compared and analyzed using IBM SPSS Statistics version 23.0.

Results: The majority of age distribution among SLE patients and controls was 21-25 years (37.5%) (Mean - 15.7 ± 14.9 years). Duration of SLE was predominantly reported between 1 and 12 months (62.5%). Very high (40%) and high (40%) lupus disease activity was recorded in the majority as per the SELENA-SLEDAI score. There was a significant difference between QTc values among SLE patients and controls (t- 8.117) (p-.0005). Upon correlating SLEDAI with the QTc, QTd, ESR, and Uric acid parameters among the SLE patients, ESR parameters were found to be moderately correlated (r-0.460) with the SLEDAI which was statistically significant (p- .003).

Conclusion: QTc interval and ESR values can be a simple and potential method for early detection of cardiac involvement in SLE patients with active disease activity. This will not only facilitate early diagnosis of disease activity, but it will also provide an affordable and accessible avenue for low and middle-income countries to decrease the SLE burden.

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系统性红斑狼疮患者心电图校正 QT 间期和 QT 弥散异常、红细胞沉降率和血清尿酸的研究。
导言系统性红斑狼疮(SLE)是一种自身免疫性疾病,由于多个器官同时受到影响或随着时间的推移逐渐受到影响,因此临床症状多种多样。除其他因素外,心血管系统(CVS)受累是系统性红斑狼疮的第三大常见死因。QT间期的测量结果表明,心血管疾病导致死亡的风险升高,因此可以通过观察QT间期来判断预后:对 80 名患者(40 名系统性红斑狼疮患者和 40 名对照组患者)进行了为期 16 个月的病例对照研究。系统性红斑狼疮患者和对照组是根据纳入标准从普通内科和风湿病门诊部(OPD)中确定的。在获得详细的临床病史后,对他们进行了全面的临床检查。然后对系统性红斑狼疮患者进行了基线验血,并对病例和对照组进行了心电图检查。使用自动分析仪测量血清尿酸水平,并使用韦斯特格伦法计算血沉。校正 QT 间期(QTc)用巴泽特法估算。所有收集到的数据均使用 IBM SPSS 统计软件 23.0 版进行比较和分析:大多数系统性红斑狼疮患者和对照组的年龄分布在 21-25 岁之间(37.5%)(平均 - 15.7 ± 14.9 岁)。据报告,系统性红斑狼疮的病程主要在 1 至 12 个月之间(62.5%)。根据 SELENA-SLEDAI 评分,大多数患者的狼疮疾病活动度都很高(40%)和很高(40%)。系统性红斑狼疮患者的 QTc 值与对照组有明显差异(t- 8.117)(p-.0005)。在将 SLEDAI 与系统性红斑狼疮患者的 QTc、QTd、血沉和尿酸参数相关联后,发现血沉参数与 SLEDAI 呈中度相关(r-0.460),具有统计学意义(p- .003):结论:QTc间期和血沉值可以作为一种简单而潜在的方法,用于早期检测疾病活动期系统性红斑狼疮患者的心脏受累情况。这不仅有助于疾病活动的早期诊断,还为中低收入国家减轻系统性红斑狼疮的负担提供了一个经济实惠、易于获得的途径。
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
期刊最新文献
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