Neurolipidomics in schizophrenia: A not so well-oiled machine

IF 4.6 2区 医学 Q1 NEUROSCIENCES Neuropharmacology Pub Date : 2024-08-15 DOI:10.1016/j.neuropharm.2024.110117
Carlos Manuel Zapata-Martín del Campo , Garth L. Nicolson , Adonis Sfera
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Abstract

Most patients with schizophrenia (SCZ) do not exhibit violent behaviors and are more likely to be victims rather than perpetrators of violent acts. However, a subgroup of forensic detainees with SCZ exhibit tendencies to engage in criminal violations. Although numerous models have been proposed, ranging from substance use, serotonin transporter gene, and cognitive dysfunction, the molecular underpinnings of violence in SCZ patients remains elusive.

Lithium and clozapine have established anti-aggression properties and recent studies have linked low cholesterol levels and ultraviolet (UV) radiation with human aggression, while vitamin D3 reduces violent behaviors. A recent study found that vitamin D3, omega-3 fatty acids, magnesium, and zinc lower aggression in forensic population.

In this review article, we take a closer look at aryl hydrocarbon receptor (AhR) and the dysfunctional lipidome in neuronal membranes, with emphasis on cholesterol and vitamin D3 depletion, as sources of aggressive behavior. We also discuss modalities to increase the fluidity of neuronal double layer via membrane lipid replacement (MLR) and natural or synthetic compounds.

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精神分裂症的神经脂质组学:运转不灵的机器。
大多数精神分裂症(SCZ)患者不会表现出暴力行为,他们更有可能成为暴力行为的受害者而非实施者。然而,在法医拘留的精神分裂症患者中,有一小部分人表现出从事违法犯罪行为的倾向。尽管从药物使用、5-羟色胺转运体基因和认知功能障碍等方面提出了许多模型,但SCZ患者暴力行为的分子基础仍然难以捉摸。锂和氯氮平具有抗攻击性,最近的研究表明,低胆固醇水平和紫外线(UV)辐射与人类攻击行为有关,而维生素 D3 可减少暴力行为。最近的一项研究发现,维生素 D3、ω-3 脂肪酸、镁和锌可降低法医人群的攻击性。在这篇综述文章中,我们将仔细研究神经元膜中的芳基烃受体(AhR)和功能失调的脂质体,重点是胆固醇和维生素 D3 的消耗,它们是攻击行为的来源。我们还讨论了通过膜脂置换(MLR)和天然或合成化合物增加神经元双层流动性的方法。
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来源期刊
Neuropharmacology
Neuropharmacology 医学-神经科学
CiteScore
10.00
自引率
4.30%
发文量
288
审稿时长
45 days
期刊介绍: Neuropharmacology publishes high quality, original research and review articles within the discipline of neuroscience, especially articles with a neuropharmacological component. However, papers within any area of neuroscience will be considered. The journal does not usually accept clinical research, although preclinical neuropharmacological studies in humans may be considered. The journal only considers submissions in which the chemical structures and compositions of experimental agents are readily available in the literature or disclosed by the authors in the submitted manuscript. Only in exceptional circumstances will natural products be considered, and then only if the preparation is well defined by scientific means. Neuropharmacology publishes articles of any length (original research and reviews).
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