Difference in expiratory flow limitations development in normoxia and hypoxia in healthy individuals

IF 1.6 4区医学 Q3 PHYSIOLOGY Respiratory Physiology & Neurobiology Pub Date : 2024-08-14 DOI:10.1016/j.resp.2024.104316

Antoine Raberin , Giorgio Manferdelli, Forrest Schorderet, Yannick Monnier, Ruben Tato Perez, Nicolas Bourdillon, Grégoire P. Millet

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Abstract

The present study investigated the maintenance/repeatability of expiratory flow limitation (EFL) between normoxia and hypoxia.

Fifty-one healthy active individuals (27 men and 24 women) performed a lung function test and a maximal incremental cycling test in both normoxia and hypoxia (inspired oxygen fraction = 0.14) on two separate visits.

During exercise in normoxia, 28 participants exhibited EFL (55 %). In hypoxia, another cohort of 28 participants exhibited EFL. The two groups only partly overlapped.

Individuals with EFL only in normoxia reported lower maximal ventilation values in hypoxia than in normoxia (n=5; −13.5 ± 7.8 %) compared to their counterparts with EFL only in hypoxia (n=5; +6.7 ± 6.3 %) or without EFL (n=18; +5.1 ± 10.3 %) (p=0.004 and p<0.001, respectively).

EFL development may be induced by different mechanisms in hypoxia vs. normoxia since the individuals who exhibited flow limitation were not the same between the two environmental conditions. This change seems influenced by the magnitude of the maximal ventilation change.

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健康人在常氧和低氧条件下呼气流量限制发展的差异。

本研究调查了呼气流量限制（EFL）在常氧和低氧之间的维持/重复性。51 名健康的运动者（27 名男性和 24 名女性）在常氧和低氧（吸入氧分压 = 0.14）环境下分别进行了肺功能测试和最大增量骑行测试。在常氧运动中，28 名参与者表现出 EFL（55%）。在低氧状态下，另一组 28 名参与者表现出 EFL。这两组只有部分重叠。与仅在缺氧状态下有 EFL 的参与者（5 人；+6.7 ± 6.3%）或没有 EFL 的参与者（18 人；+5.1 ± 10.3%）相比，仅在常氧状态下有 EFL 的参与者在缺氧状态下的最大通气值低于常氧状态下的最大通气值（5 人；-13.5 ± 7.8%）（p=0.004 和 p=0.14）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.