Oligoasthenospermia is correlated with increased preeclampsia incidence in subfertile couples undergoing in vitro fertilization and embryo transfer: a secondary analysis of a randomized clinical trial

Ling Guo M.D. , Anliang Guo Ph.D. , Xiangxin Lan M.D. , Siqi Tian M.S. , Fengxuan Sun M.D. , Yaxin Su M.S. , Zi-Jiang Chen M.D., Ph.D. , Yongzhi Cao Ph.D. , Yan Li M.D., Ph.D.
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Abstract

Objective

To evaluate whether intergroup differences in the risk of maternal pregnancy complications after in vitro fertilization (IVF) vary with male factor.

Design

A post hoc exploratory secondary analysis of data from a multicenter, randomized, controlled noninferiority trial (NCT03118141).

Setting

Academic fertility centers.

Patient(s)

A total of 1,131 subfertile women with complete recording of their male partner’s semen parameters during the trial were enrolled. All participants underwent intracytoplasmic sperm injection followed by frozen embryo transfer (ET) as part of their assisted reproductive technology treatment protocol.

Intervention(s)

Women were divided into the oligoasthenospermia (n = 405) and normospermia (n = 726) groups according to the quality of male sperm.

Main Outcome Measure(s)

Pregnancy complications, principally including the incidence of preeclampsia.

Result(s)

Notably, we found that the risk of maternal preeclampsia was significantly higher in the oligoasthenospermia group than in the normospermia group. After adjustments for confounding factors by multivariate logistic regression analysis, the incidence of preeclampsia in the oligoasthenospermia group was still significantly higher than that in the normospermia group (6.55% vs. 3.60%; odds ratio, 0.529; 95% confidence interval, 0.282–0.992). However, there were no significant differences in terms of embryo quality, cumulative live birth rate, other pregnancy complications, or neonatal outcomes between the 2 groups.

Conclusion(s)

Oligoasthenospermia was associated with a higher risk of maternal preeclampsia in subfertile couples undergoing IVF-ET treatment. In clinical practice, it is essential to thoroughly evaluate the sperm quality and quantity of male partners before IVF-ET. Further research is needed to establish the causal relationships between semen quality and adverse pregnancy complications, particularly preeclampsia, and explore potential interventions.
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在接受体外受精和胚胎移植(IVF-ET)的不育夫妇中,少精子症与子痫前期发病率增加有关:随机临床试验的二次分析。
目的评估体外受精(IVF)后母体妊娠并发症风险的组间差异是否因男性因素而异:对一项多中心、随机对照、非劣效试验(NCT03118141)的数据进行事后探索性二次分析:受试者共招募了 1131 名在试验期间完整记录了其男性伴侣精液参数的亚不育女性。作为辅助生殖技术(ART)治疗方案的一部分,所有参与者都接受了卵胞浆内单精子注射(ICSI)和冷冻胚胎移植(FET):干预措施:根据男性精子的质量将女性分为少弱精子症组(405人)和正常精子症组(726人):妊娠并发症,主要包括子痫前期的发生率:值得注意的是,我们发现少精症组产妇子痫前期的风险明显高于正常精子症组(P=0.035)。通过多变量逻辑回归分析调整混杂因素后,少精症组的子痫前期发生率仍明显高于正常精子症组(6.55% vs. 3.60%;OR=0.529;95% CI=0.282-0.992;P-adj=0.047)。然而,两组在胚胎质量、累积活产率、其他妊娠并发症或新生儿结局方面没有明显差异(P>0.05):结论:在接受IVF-ET治疗的亚育夫妇中,低精子症与较高的产妇子痫前期风险有关。在临床实践中,体外受精-胚胎移植前彻底评估男性伴侣的精子质量和数量至关重要。要确定精液质量与不良妊娠并发症(尤其是子痫前期)之间的因果关系,并探索潜在的干预措施,还需要进一步的研究。
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来源期刊
F&S science
F&S science Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Urology
CiteScore
2.00
自引率
0.00%
发文量
0
审稿时长
51 days
期刊最新文献
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