Benefit delayed immunosenescence by regulating CD4+T cells: A promising therapeutic target for aging-related diseases

IF 7.8 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Aging Cell Pub Date : 2024-08-18 DOI:10.1111/acel.14317
Tingting Xia, Ying Zhou, Jiayao An, Zhi Cui, Xinqin Zhong, Tianyi Cui, Bin Lv, Xin Zhao, Xiumei Gao
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Abstract

CD4+T cells play a notable role in immune protection at different stages of life. During aging, the interaction between the body's internal and external environment and CD4+T cells results in a series of changes in the CD4+T cells pool making it involved in immunosenescence. Many studies have extensively examined the subsets and functionality of CD4+T cells within the immune system, highlighted their pivotal role in disease pathogenesis, progression, and therapeutic interventions. However, the underlying mechanism of CD4+T cells senescence and its intricate association with diseases remains to be elucidated and comprehensively understood. By summarizing the immunosenescent progress and network of CD4+T cell subsets, we reveal the crucial role of CD4+T cells in the occurrence and development of age-related diseases. Furthermore, we provide new insights and theoretical foundations for diseases targeting CD4+T cell subsets aging as a treatment focus, offering novel approaches for therapy, especially in infections, cancers, autoimmune diseases, and other diseases in the elderly.

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通过调节 CD4+T 细胞延缓免疫衰老:有望成为衰老相关疾病的治疗靶点
在生命的不同阶段,CD4+T 细胞在免疫保护中发挥着显著的作用。在衰老过程中,机体内外环境与 CD4+T 细胞之间的相互作用导致 CD4+T 细胞池发生一系列变化,使其参与免疫衰老。许多研究广泛探讨了免疫系统中 CD4+T 细胞的亚群和功能,强调了它们在疾病发病、进展和治疗干预中的关键作用。然而,CD4+T 细胞衰老的内在机制及其与疾病的复杂联系仍有待阐明和全面了解。通过总结 CD4+T 细胞亚群的免疫衰老过程和网络,我们揭示了 CD4+T 细胞在老年相关疾病的发生和发展中的关键作用。此外,我们还为以 CD4+T 细胞亚群衰老为治疗重点的疾病提供了新的见解和理论基础,为治疗,尤其是感染、癌症、自身免疫性疾病和其他老年疾病提供了新的方法。
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来源期刊
Aging Cell
Aging Cell 生物-老年医学
CiteScore
14.40
自引率
2.60%
发文量
212
审稿时长
8 weeks
期刊介绍: Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.
期刊最新文献
Issue Information Featured Cover Correction to ‘Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single-cell analysis’ RETRACTION: 1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling Issue Information
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