Family history of arthritis, osteoporosis, and carpal tunnel syndrome and risk of these conditions among U.S. adults.

IF 3.7 2区 医学 Q1 RHEUMATOLOGY Arthritis Care & Research Pub Date : 2024-08-19 DOI:10.1002/acr.25416
Danielle Rasooly, Ramal Moonesinghe, Elizabeth Fallon, Kamil E Barbour, Muin J Khoury
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Abstract

Objective: The aim was to estimate odds ratios of associations between family history of arthritis, osteoporosis, and carpal tunnel syndrome and prevalence in a real-world population, uncovering family histories of related conditions that may increase risk due to shared heritability, condition pathophysiology, or social/environmental factors.

Methods: Using data from 156,307 participants in the All of Us (AoU) Research Program, we examined associations between self-reported first-degree family history of 5 common types of arthritis (fibromyalgia, gout, osteoarthritis (OA), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE)), osteoporosis, and carpal tunnel syndrome and prevalence. We evaluate associations across 7 conditions and performed stratified analyses by race and ethnicity, sex, socioeconomic differences, body mass index, and type of affected relative.

Results: Over 38% of AoU participants reported a family history of any arthritis, osteoporosis, or carpal tunnel syndrome. Adults with a family history of any arthritis, osteoporosis, and carpal tunnel syndrome exhibited 3.68 to 7.59 (4.90, on average) odds of having the same condition, and 0.70 to 2.10 (1.24, on average) odds of having a different condition. The strongest associations observed were between family history of OA and prevalence of OA (OR 7.59, 95%CI 7.32-7.88), and family history of SLE and prevalence of SLE (OR 6.34, 95%CI 5.17-7.74). We additionally uncover race and ethnicity and sex disparities in family history associations.

Conclusion: Family history of several related conditions was associated with increased risk for arthritis, osteoporosis, and carpal tunnel syndrome, underscoring the importance of family history of related conditions for primary prevention.

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关节炎、骨质疏松症和腕管综合征家族史与美国成年人患这些疾病的风险。
目的目的是估算现实世界人群中关节炎、骨质疏松症和腕管综合征家族史与患病率之间的几率比,揭示可能因共同遗传性、病理生理学或社会/环境因素而增加风险的相关疾病家族史:利用 "我们所有人(AoU)研究计划 "中 156,307 名参与者的数据,我们研究了自我报告的 5 种常见关节炎(纤维肌痛、痛风、骨关节炎 (OA)、类风湿性关节炎 (RA) 和系统性红斑狼疮 (SLE))、骨质疏松症和腕管综合征的一级家族史与患病率之间的关联。我们评估了 7 种疾病之间的关联,并根据种族和民族、性别、社会经济差异、体重指数和受影响亲属的类型进行了分层分析:结果:超过 38% 的奥大参与者报告有关节炎、骨质疏松症或腕管综合征家族史。有关节炎、骨质疏松症和腕管综合征家族史的成年人患相同疾病的几率为 3.68 至 7.59(平均 4.90),患不同疾病的几率为 0.70 至 2.10(平均 1.24)。所观察到的最强关联是:OA 家族史与 OA 患病率之间的关联(OR 7.59,95%CI 7.32-7.88),以及系统性红斑狼疮家族史与系统性红斑狼疮患病率之间的关联(OR 6.34,95%CI 5.17-7.74)。此外,我们还发现了家族史相关性中的种族、民族和性别差异:结论:几种相关疾病的家族史与关节炎、骨质疏松症和腕管综合征风险的增加有关,强调了相关疾病家族史对一级预防的重要性。
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来源期刊
CiteScore
9.40
自引率
6.40%
发文量
368
审稿时长
3-6 weeks
期刊介绍: Arthritis Care & Research, an official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the College), is a peer-reviewed publication that publishes original research, review articles, and editorials that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with rheumatic diseases, major topics are evidence-based practice studies, clinical problems, practice guidelines, educational, social, and public health issues, health economics, health care policy, and future trends in rheumatology practice.
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