A review of the ethnomedicinal, phytochemical, and pharmacological properties of the Ferulago genus based on Structure-Activity Relationship (SAR) of coumarins.

IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY DARU Journal of Pharmaceutical Sciences Pub Date : 2024-08-19 DOI:10.1007/s40199-024-00530-1
Farid Dabaghian, Shokoufeh Aalinezhad, Alaleh Riazati Kesheh, Niloufar Azargashb, Ramin Ansari, Mohammad Reza Shams Ardekani, Seyed Ahmad Emami, Mahnaz Khanavi, Mohammad Reza Delnavazi
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Abstract

Background: The Ferluago W.D.J. Koch genus includes 48 accepted perennial herbs that are distributed in the Mediterranean region, Southeast Europe, Central and Middle East of Asia. These plants are widely used in folk and conventional medicine due to their biological benefits such as anti-microbial, anti-inflammatory, anti-cancer, and immunomodulatory properties. Conducting a comprehensive review based on the structure activity relationships (SARs) of the coumarins, which has not been previously documented, can lead to a better insight into the genus Ferulago and its beneficial therapeutic activities.

Methods: This review covers literature from 1969 to 2023, were collected from various scientific electronic databases to review phytochemical, pharmacological, and ethnopharmacological data of Ferulago species, as well as latest information on the SAR of reported coumarins from this genus.

Results: Phytochemical studies showed that the biological actions of this genus are mediated by the reported specialized metabolites, such as coumarins and flavonoids. Simple coumarins, prenylated coumarins, furanocoumarins, and pyranocoumarins are the largest subclasses of coumarins found in diverse Ferulago species, which have discussed the biological effects of them with a focus on the Structure-Activity Relationship (SAR). For example, prenylated coumarins have shown potential leishmanicidal and anti-neuropsychiatric effects when substituted with a prenyl group at the 7-hydroxy, as well as the C6 and C8 positions in their scaffold. Similarly, furanocoumarins exhibit varied biological activities such as anti-inflammatory, anti-proliferative, and anti-convulsant effects. Modifying substitutions at the C5 and C6 positions in furanocoumarins can enhance these activities.

Conclusion: This study conducted a comprehensive review of all available information on the phytochemical and pharmacological characteristics of Ferulago species. Given the high occurrence of coumarins in this genus, which exhibit potential anti-Alzheimer and anti-microbial properties, it presents promising new therapeutic avenues for addressing these common issues. Further investigation is needed to understand the molecular-level mechanisms of action and to explore their clinical applications.

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基于香豆素的结构-活性关系(SAR),综述阿魏属植物的民族药用、植物化学和药理特性。
背景:Ferluago W.D.J. Koch 属包括 48 种公认的多年生草本植物,分布于地中海地区、欧洲东南部、亚洲中部和中东。这些植物具有抗微生物、抗炎、抗癌和免疫调节等生物功效,因此被广泛应用于民间和传统医学中。根据香豆素的结构活性关系(SARs)进行全面综述,可以更好地了解阿魏属植物及其有益的治疗活动:本综述从各种科学电子数据库中收集了1969年至2023年的文献,综述了Ferulago属植物的植物化学、药理学和民族药理学数据,以及该属已报道的香豆素SAR的最新信息:植物化学研究表明,该属植物的生物作用是由所报道的特殊代谢产物(如香豆素和黄酮类化合物)介导的。简单香豆素、前酰化香豆素、呋喃香豆素和吡喃香豆素是在不同的阿魏属植物中发现的最大的香豆素亚类,这些香豆素亚类以结构-活性关系(SAR)为重点讨论了它们的生物效应。例如,当7-羟基以及C6和C8位置上的芳基被取代时,芳基香豆素就显示出了潜在的杀利什曼和抗神经精神作用。同样,呋喃香豆素也具有多种生物活性,如抗炎、抗增殖和抗惊厥作用。在呋喃香豆素的 C5 和 C6 位置进行修饰取代可增强这些活性:本研究对有关阿魏属植物的植物化学和药理特性的所有可用信息进行了全面回顾。鉴于该属植物中含有大量香豆素,具有潜在的抗老年痴呆和抗微生物特性,这为解决这些常见问题提供了新的治疗途径。要了解其分子水平的作用机制并探索其临床应用,还需要进一步的研究。
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DARU Journal of Pharmaceutical Sciences
DARU Journal of Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-
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期刊介绍: DARU Journal of Pharmaceutical Sciences is a peer-reviewed journal published on behalf of Tehran University of Medical Sciences. The journal encompasses all fields of the pharmaceutical sciences and presents timely research on all areas of drug conception, design, manufacture, classification and assessment. The term DARU is derived from the Persian name meaning drug or medicine. This journal is a unique platform to improve the knowledge of researchers and scientists by publishing novel articles including basic and clinical investigations from members of the global scientific community in the forms of original articles, systematic or narrative reviews, meta-analyses, letters, and short communications.
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