Serum biomarkers for predicting microvascular complications of diabetes mellitus.

IF 3.9 3区医学 Q1 PATHOLOGY Expert Review of Molecular Diagnostics Pub Date : 2024-08-01 Epub Date: 2024-08-19 DOI:10.1080/14737159.2024.2391021

Jiajia Wang, Xiaoyi Song, Ziqiao Xia, Shu Feng, Hangfeng Zhang, Chengjie Xu, Hui Zhang

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Abstract

Introduction: Diabetic microvascular complications such as retinopathy, nephropathy, and neuropathy are primary causes of blindness, terminal renal failure, and neuropathic disorders in type 2 diabetes mellitus patients. Identifying reliable biomarkers promptly is pivotal for early detection and intervention in these severe complications.

Areas covered: This review offers a thorough examination of the latest research concerning serum biomarkers for the prediction and assessment of diabetic microvascular complications. It encompasses biomarkers associated with glycation, oxidative stress, inflammation, endothelial dysfunction, basement membrane thickening, angiogenesis, and thrombosis. The review also highlights the potential of emerging biomarkers, such as microRNAs and long non-coding RNAs.

Expert opinion: Serum biomarkers are emerging as valuable tools for the early assessment and therapeutic guidance of diabetic microvascular complications. The biomarkers identified not only reflect the underlying pathophysiology but also align with the extent of the disease. However, further validation across diverse populations and improvement of the practicality of these biomarkers in routine clinical practice are necessary. Pursuing these objectives is essential to advance early diagnosis, risk assessment, and individualized treatment regimens for those affected by diabetes.

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预测糖尿病微血管并发症的血清生物标志物。

导言：糖尿病微血管并发症（如视网膜病变、肾病和神经病变）是导致 2 型糖尿病患者失明、终末肾衰竭和神经病变的主要原因。及时识别可靠的生物标志物对于早期发现和干预这些严重并发症至关重要：本综述深入探讨了有关预测和评估糖尿病微血管并发症的血清生物标志物的最新研究。它包括与糖化、氧化应激、炎症、内皮功能障碍、基底膜增厚、血管生成和血栓形成有关的生物标志物。该综述还强调了新兴生物标志物的潜力，如微小核糖核酸（microRNA）和长非编码核糖核酸（long non-coding RNA）：血清生物标志物正在成为糖尿病微血管并发症早期评估和治疗指导的重要工具。已确定的生物标志物不仅能反映潜在的病理生理学，还能与疾病的程度相一致。然而，有必要在不同人群中进行进一步验证，并提高这些生物标志物在常规临床实践中的实用性。实现这些目标对于推动糖尿病患者的早期诊断、风险评估和个体化治疗方案至关重要。

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来源期刊

Expert Review of Molecular Diagnostics 医学-病理学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.