Assessment of Fetal Ventricular Size and Shape in Women With Intrahepatic Cholestasis of Pregnancy Using Speckle Tracking

IF 2.1 4区医学 Q2 ACOUSTICS Journal of Ultrasound in Medicine Pub Date : 2024-08-19 DOI:10.1002/jum.16554

Rui Li MD, Wan Wang MS, Xia Qiu MS, Ting He MS, Xiaoqin Tang MS

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Abstract

Objective

To examine the effect of intrahepatic cholestasis of pregnancy (ICP) on fetal heart morphology.

Methods

This case–control study was conducted with 40 women with ICP and 54 pregnant controls. Fetal heart quantification based on speckle tracking technology was used to assess the morphology of the fetal right and left ventricles. Routine ventricular size parameters, global and 24-segment spherical indices (SIs) were measured and compared between groups.

Results

The routine fetal cardiac parameters, global and right-ventricular SIs did not differ between the ICP and control groups. The left-ventricular apical (segments 16-24) SIs were lower in the ICP group than in the control group (P < .05), with no significant difference in the other left-ventricular segments.

Conclusions

Subclinical morphological changes were observed in the left ventricular apical segments of the fetal hearts in women with ICP, which indicates an intrauterine environment with high bile acid concentrations. Twenty-four-segment SIs can be used to effectively evaluate these changes.

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利用斑点追踪技术评估妊娠期肝内胆汁淤积症妇女的胎儿脑室大小和形状

目的：探讨妊娠期肝内胆汁淤积症（ICP）对胎儿心脏形态的影响：研究妊娠期肝内胆汁淤积症（ICP）对胎儿心脏形态的影响：这项病例对照研究的对象是 40 名患有 ICP 的孕妇和 54 名对照组孕妇。采用斑点追踪技术对胎儿心脏进行量化，以评估胎儿左右心室的形态。测量了常规心室大小参数、整体和24节球形指数（SIs），并进行了组间比较：结果：胎儿常规心脏参数、整体和右心室球形指数在ICP组和对照组之间没有差异。ICP组的左心尖（第16-24节）SIs低于对照组（P 结论：ICP组的SIs低于对照组（P）：在 ICP 孕妇的胎心左室心尖段观察到了亚临床形态学变化，这表明宫内环境中胆汁酸浓度较高。二十四节段 SI 可用于有效评估这些变化。

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来源期刊

Journal of Ultrasound in Medicine 医学-核医学

CiteScore

5.10

自引率

4.30%

发文量

205

审稿时长

1.5 months

期刊介绍： The Journal of Ultrasound in Medicine (JUM) is dedicated to the rapid, accurate publication of original articles dealing with all aspects of medical ultrasound, particularly its direct application to patient care but also relevant basic science, advances in instrumentation, and biological effects. The journal is an official publication of the American Institute of Ultrasound in Medicine and publishes articles in a variety of categories, including Original Research papers, Review Articles, Pictorial Essays, Technical Innovations, Case Series, Letters to the Editor, and more, from an international bevy of countries in a continual effort to showcase and promote advances in the ultrasound community. Represented through these efforts are a wide variety of disciplines of ultrasound, including, but not limited to: -Basic Science- Breast Ultrasound- Contrast-Enhanced Ultrasound- Dermatology- Echocardiography- Elastography- Emergency Medicine- Fetal Echocardiography- Gastrointestinal Ultrasound- General and Abdominal Ultrasound- Genitourinary Ultrasound- Gynecologic Ultrasound- Head and Neck Ultrasound- High Frequency Clinical and Preclinical Imaging- Interventional-Intraoperative Ultrasound- Musculoskeletal Ultrasound- Neurosonology- Obstetric Ultrasound- Ophthalmologic Ultrasound- Pediatric Ultrasound- Point-of-Care Ultrasound- Public Policy- Superficial Structures- Therapeutic Ultrasound- Ultrasound Education- Ultrasound in Global Health- Urologic Ultrasound- Vascular Ultrasound