Determining if Admission Thromboelastography can Predict the Development of Late Resolving Multiple Organ Failure in Trauma Patients.

IF 1 4区医学 Q3 SURGERY American Surgeon Pub Date : 2025-01-01 Epub Date: 2024-08-20 DOI:10.1177/00031348241275718

Ross P Smith, Lauren K Dwyer, Jacob C O'Dell, Christopher C McCoy, Christopher A Guidry, Robert A Winfield

{"title":"Determining if Admission Thromboelastography can Predict the Development of Late Resolving Multiple Organ Failure in Trauma Patients.","authors":"Ross P Smith, Lauren K Dwyer, Jacob C O'Dell, Christopher C McCoy, Christopher A Guidry, Robert A Winfield","doi":"10.1177/00031348241275718","DOIUrl":null,"url":null,"abstract":"Background: Normal coagulation TEG values on admission negatively correlate with overall risk of multiple organ failure, but less is known about association between coagulation and late-resolving multiple organ failure (LRMOF) risk. Here, the relationship between TEG parameters and development of LRMOF was investigated.Methods: We conducted a retrospective assessment of patients at high postinjury multiple organ failure risk at our center. The primary outcome was LRMOF.Results: Analysis included 742 patients. Demographics were 76% male, mean age of 41, mean ISS of 23, 34% hypercoagulability, and 16% developed LRMOF. Patients with normal admission TEG developed LRMOF at significantly lower unadjusted rates than patients with coagulation disturbances (9 vs 16%-19%, P = 0.029); however, multivariable logistic regression demonstrated that neither coagulation profile nor individual admission TEG parameters showed association with LRMOF.Conclusions: In this series, we found no significant relationship between coagulation status and LRMOF development.","PeriodicalId":7782,"journal":{"name":"American Surgeon","volume":" ","pages":"38-41"},"PeriodicalIF":1.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Surgeon","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00031348241275718","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Normal coagulation TEG values on admission negatively correlate with overall risk of multiple organ failure, but less is known about association between coagulation and late-resolving multiple organ failure (LRMOF) risk. Here, the relationship between TEG parameters and development of LRMOF was investigated.

Methods: We conducted a retrospective assessment of patients at high postinjury multiple organ failure risk at our center. The primary outcome was LRMOF.

Results: Analysis included 742 patients. Demographics were 76% male, mean age of 41, mean ISS of 23, 34% hypercoagulability, and 16% developed LRMOF. Patients with normal admission TEG developed LRMOF at significantly lower unadjusted rates than patients with coagulation disturbances (9 vs 16%-19%, P = 0.029); however, multivariable logistic regression demonstrated that neither coagulation profile nor individual admission TEG parameters showed association with LRMOF.

Conclusions: In this series, we found no significant relationship between coagulation status and LRMOF development.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

确定入院血栓弹性成像能否预测创伤患者晚期多器官功能衰竭的发展。

背景：入院时凝血功能正常的 TEG 值与多器官功能衰竭的总体风险呈负相关，但凝血功能与晚期多器官功能衰竭（LRMOF）风险之间的关系却鲜为人知。在此，我们研究了 TEG 参数与 LRMOF 发生之间的关系：我们对本中心的伤后多器官功能衰竭高危患者进行了回顾性评估。主要结果是 LRMOF：分析包括 742 名患者。男性占 76%，平均年龄为 41 岁，平均 ISS 为 23，34% 患有高凝状态，16% 患有 LRMOF。入院时 TEG 正常的患者发生 LRMOF 的比例明显低于凝血功能紊乱的患者（9 vs 16%-19%，P = 0.029）；然而，多变量逻辑回归表明，凝血功能状况和个别入院 TEG 参数均与 LRMOF 无关：在该系列研究中，我们发现凝血状态与 LRMOF 的发生无明显关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

American Surgeon 医学-外科

CiteScore

1.40

自引率

0.00%

发文量

623

期刊介绍： The American Surgeon is a monthly peer-reviewed publication published by the Southeastern Surgical Congress. Its area of concentration is clinical general surgery, as defined by the content areas of the American Board of Surgery: alimentary tract (including bariatric surgery), abdomen and its contents, breast, skin and soft tissue, endocrine system, solid organ transplantation, pediatric surgery, surgical critical care, surgical oncology (including head and neck surgery), trauma and emergency surgery, and vascular surgery.