Medication non-adherence and associated factors among peoples with schizophrenia: multicenter cross-sectional study in Northwest Ethiopia.

IF 3.4 2区医学 Q2 PSYCHIATRY BMC Psychiatry Pub Date : 2024-08-19 DOI:10.1186/s12888-024-06004-7

Fasil Bayafers Tamene, Endalamaw Aschale Mihiretie, Abiy Mulugeta, Abenet Kassaye, Kale Gubae, Samuel Agegnew Wondm

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Abstract

Background: Schizophrenia is a serious and debilitating psychiatric disorder that is linked to marked social and occupational impairment. Despite the vital relevance of medication, non-adherence with recommended pharmacological treatments has been identified as a worldwide problem and is perhaps the most difficult component of treating schizophrenia. There are limited studies conducted on magnitude and potential factors of medication non-adherence among peoples with schizophrenia in Ethiopia.

Objectives: This study aimed to assess medication non-adherence and associated factors among peoples with schizophrenia at comprehensive specialized hospitals in Northwest Ethiopia.

Methods: An institutional-based cross-sectional study was conducted among 387 peoples with schizophrenia at selected hospitals in the Northwest of Ethiopia from June to August 2022. Study participants were enrolled using systematic random sampling. Medication non-adherence was measured using Medication Adherence Rating Scale (MARS). Data entry and analysis were done using Epi-data version 4.6.0 and SPSS version 24, respectively. A multivariable logistic regression model was fitted to identify factors associated with medication non-adherence. Variables with a p-value of < 0.05 at a 95% confidence interval were considered statistically significant.

Results: The prevalence of medication non-adherence was 51.2% (95% CI: 46.3, 56.3). Duration of treatment for more than ten years (AOR = 3.76, 95% CI: 1.43, 9.89), substance use (AOR = 1.92, 95% CI: 1.17, 3.13), antipsychotic polypharmacy, (AOR = 2.01, 95% CI: 1.11, 3.63) and extra-pyramidal side effect (AOR = 2.48, 95% CI: 1.24, 4.94) were significantly associated with medication non-adherence.

Conclusion: In this study, half of the participants were found to be medication non-adherent. Respondents with a longer duration of treatment, substance users, those on antipsychotic polypharmacy, and those who develop extra-pyramidal side effect need prompt screening and critical follow-up to improve medication adherence.

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精神分裂症患者不遵医嘱用药及其相关因素：埃塞俄比亚西北部多中心横断面研究。

背景：精神分裂症是一种严重的、使人衰弱的精神疾病，与明显的社会和职业障碍有关。尽管药物治疗至关重要，但不坚持推荐的药物治疗已被确定为一个世界性问题，这也许是治疗精神分裂症最困难的部分。有关埃塞俄比亚精神分裂症患者不坚持服药的程度和潜在因素的研究十分有限：本研究旨在评估埃塞俄比亚西北部综合专科医院精神分裂症患者不坚持服药的情况及其相关因素：2022年6月至8月，在埃塞俄比亚西北部选定的医院对387名精神分裂症患者进行了一项以机构为基础的横断面研究。研究参与者采用系统随机抽样的方式进行登记。用药依从性评定量表（MARS）衡量用药不依从情况。数据录入和分析分别使用 Epi-data 4.6.0 版和 SPSS 24 版。为确定与不坚持用药相关的因素，我们建立了一个多变量逻辑回归模型。结果显示，P 值为 0 的变量与不遵医嘱用药的发生率成正比：不遵医嘱用药的发生率为 51.2%（95% CI：46.3，56.3）。治疗时间超过 10 年（AOR = 3.76，95% CI：1.43，9.89）、药物使用（AOR = 1.92，95% CI：1.17，3.13）、抗精神病多药（AOR = 2.01，95% CI：1.11，3.63）和锥体外系副作用（AOR = 2.48，95% CI：1.24，4.94）与不遵医嘱用药显著相关：结论：本研究发现，半数受试者不坚持用药。治疗时间较长的受访者、药物使用者、服用抗精神病药物的患者以及出现锥体外系副作用的患者需要及时筛查和严格随访，以提高服药依从性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.