Choroidal imaging biomarkers as predictors of conversion to exudative age-related macular degeneration.

IF 2.4 3区医学 Q2 OPHTHALMOLOGY Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-08-20 DOI:10.1007/s00417-024-06611-w

Arman Zarnegar, Nicola Valsecchi, Elham Sadeghi, Stavan Shah, Anthony Tang, Shiva Yagobian, Danilo Iannetta, Jay Chhablani

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Abstract

Purpose: Predicting the progression of intermediate AMD (iAMD) to neovascular AMD (nAMD) will help to identify high-risk patients and improve treatment outcomes. The present study assessed whether choroidal OCT biomarkers could predict conversion to nAMD.

Methods: This retrospective study included patients with clinically stable iAMD who either converted to nAMD (C group) or did not convert (NC group) during one year of follow-up. OCT parameters included subfoveal choroidal thickness (SFCT), central macular thickness (CMT), Haller vascular thickness (HVT), inner choroidal thickness (ICT), and double-layer sign (DLS).

Results: Of 116 total eyes, there were 37 in the NC group and 79 in the C group. Baseline SFCT was significantly lower in the C group compared to the NC group (169.0 ± 63.2 μm vs. 218.0 ± 97.8 μm, p = 0.01). Baseline HVT and ICT were lower in the C group (105.2 ± 40.6 μm vs. 121.0 ± 56.6 μm, p = 0.17 and 61.9 ± 35.5 μm vs. 77.5 ± 41.7 μm, p = 0.09). HVT was decreased at all time points in the C group vs NC (p > 0.05). The ICT was reduced in the C group at each time point except at conversion time (p > 0.05). Of all eight eyes who presented DLS at baseline, 100% converted to nAMD (p < 0.001).

Conclusion: Lower SFCT at baseline may signal conversion to nAMD within 12 months.

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预测渗出性老年性黄斑变性的脉络膜成像生物标志物。

目的：预测中度AMD（iAMD）向新生血管性AMD（nAMD）的进展将有助于识别高危患者并改善治疗效果。本研究评估了脉络膜 OCT 生物标志物能否预测向 nAMD 的转化：这项回顾性研究纳入了临床稳定的 iAMD 患者，他们在一年的随访期间要么转为 nAMD（C 组），要么没有转为 nAMD（NC 组）。OCT 参数包括眼底脉络膜厚度 (SFCT)、黄斑中心厚度 (CMT)、Haller 血管厚度 (HVT)、内脉络膜厚度 (ICT) 和双层征 (DLS)：在116只眼睛中，NC组有37只，C组有79只。C组的基线SFCT明显低于NC组（169.0 ± 63.2 μm vs. 218.0 ± 97.8 μm，p = 0.01）。C 组的基线 HVT 和 ICT 较低（105.2 ± 40.6 μm vs. 121.0 ± 56.6 μm，p = 0.17 和 61.9 ± 35.5 μm vs. 77.5 ± 41.7 μm，p = 0.09）。与 NC 相比，C 组的 HVT 在所有时间点均有所下降（p > 0.05）。除转换时间外，C 组的 ICT 在每个时间点都有所下降（p > 0.05）。在基线时出现 DLS 的所有八只眼睛中，100% 转化为 nAMD（p 结论：基线时较低的 SFCT 可能会导致 nAMD：基线时较低的 SFCT 可能是 12 个月内转为 nAMD 的信号。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Graefe’s Archive for Clinical and Experimental Ophthalmology 医学-眼科学

CiteScore

5.40

自引率

7.40%

发文量

398

审稿时长

3 months

期刊介绍： Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.