Primary hyperparathyroidism: from guidelines to outpatient clinic.

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI:10.1007/s11154-024-09899-5
Andrea Palermo, Gaia Tabacco, Polyzois Makras, Guido Zavatta, Pierpaolo Trimboli, Elena Castellano, Maria P Yavropoulou, Anda Mihaela Naciu, Athanasios D Anastasilakis
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Abstract

Primary hyperparathyroidism (PHPT) is a common endocrine disease characterized by hypercalcemia due to inappropriately high parathyroid hormone secretion. While in the typical, symptomatic form of the disease diagnosis is set easily and standard management is surgical removal of the hyperfunctioning parathyroid (HP), this may not be the case in more subtle forms of PHPT, such as the asymptomatic and the normocalcemic PHPT. Localization of the HP could also be challenging, especially in small-sized adenomas, ectopic lesions or multiglandular disease. An experienced surgical team is essential to achieve curative parathyroidectomy. In this article, we used illustrative clinical vignettes to dissect the approach to the patient with PHPT, from the diagnosis establishment to the suggested investigation to identify classical and non-classical PHPT features and the methodology to locate the abnormal tissue. Accordingly, we elaborated on appropriate management, both surgical and conservative.

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原发性甲状旁腺功能亢进症:从指南到门诊。
原发性甲状旁腺功能亢进症(PHPT)是一种常见的内分泌疾病,其特点是甲状旁腺激素分泌过高导致高钙血症。典型的无症状型甲状旁腺功能亢进症很容易确诊,标准治疗方法是手术切除功能亢进的甲状旁腺(HP)。甲状旁腺功能减退症的定位也很困难,尤其是在小腺瘤、异位病变或多腺体疾病中。经验丰富的手术团队对于实现治愈性甲状旁腺切除术至关重要。在这篇文章中,我们使用了一些临床案例来剖析治疗 PHPT 患者的方法,从诊断的确立到建议进行的检查,以确定经典和非经典 PHPT 特征,以及定位异常组织的方法。相应地,我们还阐述了适当的治疗方法,包括手术治疗和保守治疗。
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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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