Ana Luiza Cabral de Ávila Andrade, Yasmin Dias de Almeida Pinto, Bernardo Emerenciano Barros Maia, Joice Dias Corrêa, Diogo de Azevedo Miranda, Flávio Ricardo Manzi, Izabella Lucas de Abreu Lima
{"title":"Genetic polymorphisms in external apical root resorption and orthodontic tooth movements: A systematic review.","authors":"Ana Luiza Cabral de Ávila Andrade, Yasmin Dias de Almeida Pinto, Bernardo Emerenciano Barros Maia, Joice Dias Corrêa, Diogo de Azevedo Miranda, Flávio Ricardo Manzi, Izabella Lucas de Abreu Lima","doi":"10.4041/kjod24.030","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>External apical root resorption (EARR) is characterized by permanent loss of dental structure at the root apex. This study aimed to systematically review gene polymorphisms associated with EARR in orthodontic patients.</p><p><strong>Methods: </strong>Electronic database searches were performed across several databases.</p><p><strong>Results: </strong>This systematic review included 21 studies. Outcome measures were based on tooth dimensions observed on radiographs obtained before and after treatment. Polymorphisms in the following genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis: purinergic-receptor-P2X, ligand-gated ion channel 7 (<i>P2RX7</i>), caspase-1/interleukin-converting enzyme (<i>CASP1</i>/<i>ICE</i>), caspase-5 (<i>CASP5</i>), IL-1beta (<i>IL1B</i>), IL-1alpha (<i>IL1A</i>), interleukin-1 receptor antagonist gene (<i>IL1RN</i>), tissue non-specific alkaline phosphatase (<i>TNSALP</i>), tumor necrosis factor-alpha (<i>TNFα</i>), tumor necrosis factor receptor superfamily gene member 11a (<i>TNFRSF11A</i>), secreted phosphoprotein 1 (<i>SPP1</i>), tumor necrosis factor receptor superfamily gene member 11b (<i>TNFRSF11B</i>), interleukin 17A (<i>IL17</i>), interleukin 6 (<i>IL6</i>), receptor activator of nuclear factor-kappa B (<i>RANK</i>), osteoprotegerin (<i>OPG</i>), stromal antigen 2 (<i>STAG2</i>), vitamin D receptor (<i>VDR</i>), cytochrome P450 family 24 subfamily A member 1 (<i>CYP24A1</i>), cytochrome P450 family 27 subfamily B (<i>CYP27B1</i>), group-specific component (<i>GC</i>), and interleukin-1 receptor-associated kinases 1 (<i>IRAK1</i>).</p><p><strong>Conclusions: </strong>Almost all studies suggested that IL1 gene is associated with EARR. Additionally, <i>P2RX7</i> may be an important factor contributing to the etiopathogenesis of EARR. <i>TNFRSF11A</i>, <i>SPP1</i>, <i>IL1RN</i>, <i>IL6</i>, <i>TNFRSF11B</i>, <i>STAG2</i>, <i>VDR</i>, <i>IRAK1</i>, <i>IL-17</i>, <i>CASP1</i>/<i>ICE</i> and <i>CASP5</i> have been identified in isolated studies. Further observational studies are needed to better explain the association between these genes and EARR.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":" ","pages":"284-302"},"PeriodicalIF":2.6000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422680/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Orthodontics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4041/kjod24.030","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: External apical root resorption (EARR) is characterized by permanent loss of dental structure at the root apex. This study aimed to systematically review gene polymorphisms associated with EARR in orthodontic patients.
Methods: Electronic database searches were performed across several databases.
Results: This systematic review included 21 studies. Outcome measures were based on tooth dimensions observed on radiographs obtained before and after treatment. Polymorphisms in the following genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis: purinergic-receptor-P2X, ligand-gated ion channel 7 (P2RX7), caspase-1/interleukin-converting enzyme (CASP1/ICE), caspase-5 (CASP5), IL-1beta (IL1B), IL-1alpha (IL1A), interleukin-1 receptor antagonist gene (IL1RN), tissue non-specific alkaline phosphatase (TNSALP), tumor necrosis factor-alpha (TNFα), tumor necrosis factor receptor superfamily gene member 11a (TNFRSF11A), secreted phosphoprotein 1 (SPP1), tumor necrosis factor receptor superfamily gene member 11b (TNFRSF11B), interleukin 17A (IL17), interleukin 6 (IL6), receptor activator of nuclear factor-kappa B (RANK), osteoprotegerin (OPG), stromal antigen 2 (STAG2), vitamin D receptor (VDR), cytochrome P450 family 24 subfamily A member 1 (CYP24A1), cytochrome P450 family 27 subfamily B (CYP27B1), group-specific component (GC), and interleukin-1 receptor-associated kinases 1 (IRAK1).
Conclusions: Almost all studies suggested that IL1 gene is associated with EARR. Additionally, P2RX7 may be an important factor contributing to the etiopathogenesis of EARR. TNFRSF11A, SPP1, IL1RN, IL6, TNFRSF11B, STAG2, VDR, IRAK1, IL-17, CASP1/ICE and CASP5 have been identified in isolated studies. Further observational studies are needed to better explain the association between these genes and EARR.
期刊介绍：
The Korean Journal of Orthodontics (KJO) is an international, open access, peer reviewed journal published in January, March, May, July, September, and November each year. It was first launched in 1970 and, as the official scientific publication of Korean Association of Orthodontists, KJO aims to publish high quality clinical and scientific original research papers in all areas related to orthodontics and dentofacial orthopedics. Specifically, its interest focuses on evidence-based investigations of contemporary diagnostic procedures and treatment techniques, expanding to significant clinical reports of diverse treatment approaches.
The scope of KJO covers all areas of orthodontics and dentofacial orthopedics including successful diagnostic procedures and treatment planning, growth and development of the face and its clinical implications, appliance designs, biomechanics, TMJ disorders and adult treatment. Specifically, its latest interest focuses on skeletal anchorage devices, orthodontic appliance and biomaterials, 3 dimensional imaging techniques utilized for dentofacial diagnosis and treatment planning, and orthognathic surgery to correct skeletal disharmony in association of orthodontic treatment.
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