Structural Classification Insights Into the Plant Defensive Peptides.

IF 3.2 4区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Proteins-Structure Function and Bioinformatics Pub Date : 2024-12-01 Epub Date: 2024-08-20 DOI:10.1002/prot.26736

Inda Setyawati, Ahmad Fadhlullah Husaini, Aprijal Ghiyas Setiawan, I Made Artika, Laksmi Ambarsari, Waras Nurcholis, Keni Vidilaseris, Popi Asri Kurniatin

引用次数: 0

Abstract

This study presents a structural phylogenetic analysis of plant defensive peptides, revealing their evolutionary relationships, structural diversification, and functional adaptations. Utilizing a robust dataset comprising both experimental and predicted structures sourced from the RCSB Protein Data Bank and AlphaFold DB, we constructed a detailed phylogenetic tree to elucidate the distinct evolutionary paths of plant defensive peptide families. Our findings showcase the evolutionary intricacies of defensive peptides, highlighting their diversity and the conservation of key structural motifs critical to their antimicrobial or defensive functions. The results also underscore the adaptive significance of defensive peptides in plant evolution, highlighting their roles in responding to ecological pressures and pathogen interactions.

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植物防御肽的结构分类见解

本研究对植物防御肽进行了结构系统发育分析，揭示了它们的进化关系、结构多样化和功能适应性。我们利用由来自 RCSB 蛋白质数据库和 AlphaFold DB 的实验结构和预测结构组成的强大数据集，构建了一棵详细的系统发生树，以阐明植物防御肽家族的独特进化路径。我们的研究结果展示了防御肽进化的复杂性，突出了防御肽的多样性以及对其抗菌或防御功能至关重要的关键结构基元的保存。研究结果还强调了防御肽在植物进化中的适应意义，突出了它们在应对生态压力和病原体相互作用方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Proteins-Structure Function and Bioinformatics 生物-生化与分子生物学

CiteScore

5.90

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： PROTEINS : Structure, Function, and Bioinformatics publishes original reports of significant experimental and analytic research in all areas of protein research: structure, function, computation, genetics, and design. The journal encourages reports that present new experimental or computational approaches for interpreting and understanding data from biophysical chemistry, structural studies of proteins and macromolecular assemblies, alterations of protein structure and function engineered through techniques of molecular biology and genetics, functional analyses under physiologic conditions, as well as the interactions of proteins with receptors, nucleic acids, or other specific ligands or substrates. Research in protein and peptide biochemistry directed toward synthesizing or characterizing molecules that simulate aspects of the activity of proteins, or that act as inhibitors of protein function, is also within the scope of PROTEINS. In addition to full-length reports, short communications (usually not more than 4 printed pages) and prediction reports are welcome. Reviews are typically by invitation; authors are encouraged to submit proposed topics for consideration.