Polymers produced with depolymerase

IF 12.9 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature chemical biology Pub Date : 2024-08-20 DOI:10.1038/s41589-024-01723-0
Russell Johnson
{"title":"Polymers produced with depolymerase","authors":"Russell Johnson","doi":"10.1038/s41589-024-01723-0","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":null,"pages":null},"PeriodicalIF":12.9000,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature chemical biology","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41589-024-01723-0","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
用解聚酶生产的聚合物
许多塑料在环境中无法降解。改用可生物降解和可堆肥的聚合物进行生产,为设计塑料固有的有限使用寿命提供了一条途径,从而确保废塑料不会在环境中持续存在。聚乳酸(PLA)是一种广泛使用的生物聚合物,但只有在工业堆肥的高温条件下才能有效降解;在家庭堆肥和土壤条件下的生物降解率很低。首先,Guicherd 等人从嗜热细菌 Actinomadura keratinilytica T16-1 中分离并纯化出一种新的聚乳酸解聚酶,他们称之为 PAM。表征结果表明,与蛋白酶 K(一种常用酶)相比,PAM 对聚乳酸解聚更有活性。随后,研究小组利用 X 射线晶体学技术解决了 PAM 的结构问题,从而建立了其解聚酶活性模型。接下来,研究小组在 PAM 中引入突变,创造出一种高效的解聚酶。聚乳酸塑料的加工过程在高温下进行,这会使酶失活,因此 Guicherd 等人通过将 PAM 的有益突变接枝到恒温支架上,创造出了一种超恒温聚乳酸水解酶。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Nature chemical biology
Nature chemical biology 生物-生化与分子生物学
CiteScore
23.90
自引率
1.40%
发文量
238
审稿时长
12 months
期刊介绍: Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.
期刊最新文献
A tRNA modification with aminovaleramide facilitates AUA decoding in protein synthesis Compact RNA editors with natural miniature Cas13j nucleases Beware of extreme calculated lipophilicity when designing cyclic peptides Anti-aggregate activity Sweet RNA
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1