Tinatin Muradashvili, Mansen Yu, Sabrina L. Browning, Noffar Bar, Elan Gorshein, Terri L. Parker, Natalia Neparidze
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单克隆丙种球蛋白病（MG）是一系列相关疾病的总称，其中以意义未定的单克隆丙种球蛋白病（MGUS）最为常见。在每一例淤积性多发性骨髓瘤（SMM）和临床多发性骨髓瘤（MM）发生之前，都会出现 MGUS。从MGUS发展为MM的风险约为每年1%[1]，而对于SMM患者来说，2年内发展为MM的风险可高达63%[2]。虽然人们已经认识到 MG 与代谢状况之间存在关联，但确切的致病机制仍难以确定。肥胖可能被认为是从 MGUS 发展为 MM 的一个重要因素，也是 MM 死亡率较高的一个重要因素[3]。相反，肥胖者可能会改善复发/难治性 MM 的无进展生存期和总生存期[4]。然而，体重指数并不影响因 MM 而接受造血干细胞移植的患者的死亡率[5]。
期刊介绍：
Title: Leukemia
Journal Overview:
Publishes high-quality, peer-reviewed research
Covers all aspects of research and treatment of leukemia and allied diseases
Includes studies of normal hemopoiesis due to comparative relevance
Topics of Interest:
Oncogenes
Growth factors
Stem cells
Leukemia genomics
Cell cycle
Signal transduction
Molecular targets for therapy
And more
Content Types:
Original research articles
Reviews
Letters
Correspondence
Comments elaborating on significant advances and covering topical issues
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