Continuous reference intervals for holotranscobalamin, homocysteine and folate in a healthy paediatric cohort.

IF 2.1 4区医学 Q3 MEDICAL LABORATORY TECHNOLOGY Annals of Clinical Biochemistry Pub Date : 2024-11-01 Epub Date: 2024-08-30 DOI:10.1177/00045632241280344

Joel D Smith, Vasiliki Karlaftis, Stephen Hearps, Chantal Attard, Helen Savoia, Janine Campbell, Paul Monagle

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Abstract

Background: The detection of deficiencies in B₁₂ and folate children is important. However, despite the availability of various markers to assess B₁₂ and folate metabolism, there are limited studies describing the reference intervals (RIs) and changes during growth and development for these markers in healthy children.

Methods: Using samples collected from 378 children aged 30 days-< 18 years, we derived continuous RIs for holotranscobalamin, homocysteine and red cell folate.

Results: The lower RI for holotranscobalamin was lowest at birth, rising during early childhood and then declining following ages 4-6 years whereas red cell folate was highest early in life and then declined steadily towards adulthood. Total homocysteine, reflective of both B₁₂ and folate status was elevated early in life, reaching a nadir at age 2 and then increasing towards adulthood.

Conclusions: Continuous central 95^th percentile RI for holotranscobalamin, homocysteine and red cell folate for children ages 30 days to <18 years were established. Each marker shows dynamic changes throughout childhood and adolescence which will assist clinicians in more appropriately assessing B₁₂ and folate status in this population.

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健康儿童队列中全反式钴胺素、同型半胱氨酸和叶酸的连续参考区间。

背景儿童 B12 和叶酸缺乏症的检测非常重要。然而，尽管有各种标记物可用于评估 B12 和叶酸代谢，但描述这些标记物在健康儿童生长发育过程中的参考区间（RIs）和变化的研究却很有限。方法我们利用从 378 名年龄在 30 天-18 岁之间的儿童身上采集的样本，得出了全反式钴胺、同型半胱氨酸和红细胞叶酸的连续参考区间。结果全转铁蛋白的较低 RI 在出生时最低，在幼儿期上升，4-6 岁后下降，而红细胞叶酸在生命早期最高，成年后稳步下降。反映 B12 和叶酸状况的总同型半胱氨酸在生命早期升高，2 岁时达到最低点，成年后逐渐升高。结论 30 天至 6 岁儿童的全反式钴胺素、同型半胱氨酸和红细胞叶酸的连续中央 95 百分位数 RI

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical Biochemistry Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

5.20

自引率

4.50%

发文量

期刊介绍： Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine. Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal''s scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals. Annals of Clinical Biochemistry is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).