Targeting 8-oxoguanine DNA glycosylase-1 (OGG1) as a therapeutic strategy in inflammatory-related diseases.

IF 2.9 4区医学 Q3 IMMUNOLOGY Immunopharmacology and Immunotoxicology Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI:10.1080/08923973.2024.2391471

Abdullahi Samaila, Rusliza Basir, Mukhtar Gambo Lawal, Razif Abas, Maizaton Atmadini Abdullah, Roslaini Abd Majid, Norshariza Nordin, Mohd Khairi Hussain, Nur Izah Ab Razak, Yong Yoke Keong, Basiru Aliyu

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Abstract

Objective: Inflammatory diseases are influenced by oxidative stress. Oxidatively damaged 8-oxoG in DNA is linked to inflammation. The enzyme OGG1 is responsible for repairing the damaged base in the DNA which is linked to pro-inflammatory signaling and severe inflammation. This study aims to explore the potential of targeting OGG1 as a therapeutic strategy in inflammatory disease conditions.

Methods: A comprehensive search and review of literature were conducted using appropriate scientific databases such as Google Scholar, Scopus, PubMed, Web of Science, and other references to obtain relevant information that suited the title and content of this article.

Results: Compelling pieces of evidence from many previous studies have shown the crucial role of the OGG1/8oxoG pathway in inflammatory disease conditions, leading to severe inflammatory response and death. Therefore, based on these pieces of evidence, targeting this enzyme (OGG1) using specific pharmacological inhibitors or interventions might lead to downregulation and amelioration of severe inflammation to reduce the morbimortality related to several disease conditions.

Conclusion: This review highlighted the molecular mechanism of OGG1 activity via the 8-oxo/OGG1 pathway and its role in inflammation and inflammatory disease conditions. Due to the paucity of studies involving OGG1in inflammatory infectious diseases, further research projects are needed to explore the therapeutic potential of various OGG1 inhibitors to serve as novel therapeutic strategies in infectious inflammatory diseases of medical importance in developing countries such as malaria, meningitis, tuberculosis among others.

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将 8-oxoguanine DNA 糖基化酶-1 (OGG1) 作为治疗炎症相关疾病的靶点。

目的：炎症性疾病受到氧化应激的影响：炎症性疾病受氧化应激的影响。DNA 中被氧化破坏的 8-oxoG 与炎症有关。OGG1酶负责修复DNA中受损的碱基，这与促炎信号传导和严重炎症有关。本研究旨在探索靶向 OGG1 作为炎症性疾病治疗策略的潜力：方法：利用谷歌学者、Scopus、PubMed、Web of Science 等适当的科学数据库和其他参考文献对文献进行了全面搜索和综述，以获取符合本文标题和内容的相关信息：以往许多研究中令人信服的证据表明，OGG1/8oxoG 通路在炎症疾病中起着至关重要的作用，会导致严重的炎症反应和死亡。因此，基于这些证据，使用特定的药理抑制剂或干预措施来靶向这种酶（OGG1）可能会导致严重炎症的下调和改善，从而降低与多种疾病相关的死亡率：本综述强调了OGG1通过8-oxo/OGG1通路发挥活性的分子机制及其在炎症和炎症性疾病中的作用。由于涉及 OGG1 在炎症性传染病中作用的研究较少，因此需要开展进一步的研究项目，探索各种 OGG1 抑制剂的治疗潜力，将其作为新型治疗策略，用于治疗在发展中国家具有重要医疗意义的炎症性传染病，如疟疾、脑膜炎、肺结核等。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunopharmacology and Immunotoxicology 医学-毒理学

CiteScore

5.40

自引率

0.00%

发文量

133

审稿时长

4-8 weeks

期刊介绍： The journal Immunopharmacology and Immunotoxicology is devoted to pre-clinical and clinical drug discovery and development targeting the immune system. Research related to the immunoregulatory effects of various compounds, including small-molecule drugs and biologics, on immunocompetent cells and immune responses, as well as the immunotoxicity exerted by xenobiotics and drugs. Only research that describe the mechanisms of specific compounds (not extracts) is of interest to the journal. The journal will prioritise preclinical and clinical studies on immunotherapy of disorders such as chronic inflammation, allergy, autoimmunity, cancer etc. The effects of small-drugs, vaccines and biologics against central immunological targets as well as cell-based therapy, including dendritic cell therapy, T cell adoptive transfer and stem cell therapy, are topics of particular interest. Publications pointing towards potential new drug targets within the immune system or novel technology for immunopharmacological drug development are also welcome. With an immunoscience focus on drug development, immunotherapy and toxicology, the journal will cover areas such as infection, allergy, inflammation, tumor immunology, degenerative disorders, immunodeficiencies, neurology, atherosclerosis and more. Immunopharmacology and Immunotoxicology will accept original manuscripts, brief communications, commentaries, mini-reviews, reviews, clinical trials and clinical cases, on the condition that the results reported are based on original, clinical, or basic research that has not been published elsewhere in any journal in any language (except in abstract form relating to paper communicated to scientific meetings and symposiums).