Antonio Frontera MD, PhD, Andrea Mazzanti MD, PhD, Bernard Belhassen MD, Silvia Priori MD, PhD
{"title":"Induction of ventricular fibrillation during programmed ventricular stimulation in a patient with CASQ2 heterozygous mutation","authors":"Antonio Frontera MD, PhD, Andrea Mazzanti MD, PhD, Bernard Belhassen MD, Silvia Priori MD, PhD","doi":"10.1111/jce.16406","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>We report the case of a 37-year-old male athlete, who developed during exercise atrial and ventricular arrhythmias. No structural heart disease.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Invasive programmed ventricular stimulation induced ventricular fibrillation. A heterozygous mutation in the <i>CASQ2</i> gene (c.775G>T, p.E259X) was found.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The findings in our patient may suggest some increased ventricular excitability using programmed ventricular stimulation in <i>CASQ2</i> polymorphic ventricular tachycardia patients.</p>\n </section>\n </div>","PeriodicalId":15178,"journal":{"name":"Journal of Cardiovascular Electrophysiology","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jce.16406","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Electrophysiology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jce.16406","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction
We report the case of a 37-year-old male athlete, who developed during exercise atrial and ventricular arrhythmias. No structural heart disease.
Results
Invasive programmed ventricular stimulation induced ventricular fibrillation. A heterozygous mutation in the CASQ2 gene (c.775G>T, p.E259X) was found.
Conclusions
The findings in our patient may suggest some increased ventricular excitability using programmed ventricular stimulation in CASQ2 polymorphic ventricular tachycardia patients.
期刊介绍:
Journal of Cardiovascular Electrophysiology (JCE) keeps its readership well informed of the latest developments in the study and management of arrhythmic disorders. Edited by Bradley P. Knight, M.D., and a distinguished international editorial board, JCE is the leading journal devoted to the study of the electrophysiology of the heart.