Intranasal Trigeminal Function in Aging Adults.

IF 2.5 3区 医学 Q1 OTORHINOLARYNGOLOGY American Journal of Rhinology & Allergy Pub Date : 2024-11-01 Epub Date: 2024-08-21 DOI:10.1177/19458924241274973
Noah Z Feit, Nicole Kloosterman, Kristina A LaPointe, Charn Pitiranggon, Isabel E Finnegan, Carter D Smith, Mathew J Gregoski, Nicholas R Rowan, Zachary M Soler, Rodney J Schlosser
{"title":"Intranasal Trigeminal Function in Aging Adults.","authors":"Noah Z Feit, Nicole Kloosterman, Kristina A LaPointe, Charn Pitiranggon, Isabel E Finnegan, Carter D Smith, Mathew J Gregoski, Nicholas R Rowan, Zachary M Soler, Rodney J Schlosser","doi":"10.1177/19458924241274973","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Intranasal trigeminal function is important in detecting environmental stimuli. The impact of age-associated chemosensory dysfunction upon taste and olfaction is well described, but an understanding of trigeminal loss (chemesthesis) is lacking.</p><p><strong>Objective: </strong>The goal of this study was to characterize trigeminal function in a cohort of older adults and explore potential impacts.</p><p><strong>Methods: </strong>Twenty-eight participants over 50 years of age were recruited from the community as part of an aging cohort study. This nested cohort completed chemosensory questionnaires, patient-reported outcome measures (PROMs), and psychophysical testing for taste (taste strips), olfaction (Sniffin' Sticks), and trigeminal function (eucalyptol lateralization). Data were analyzed for associations between trigeminal function, olfactory, and taste psychophysical performance, patient-reported metrics, and demographic risk factors.</p><p><strong>Results: </strong>Patient-reported trigeminal impairment is less severe than other chemosensory loss, with mean visual analog scores (VAS, rated 0-100 from least to most severe) for smell (32.9 ± 34.2), taste (20.6 ± 28.4), and trigeminal sensation (9.5 ± 12.8). Despite low VAS scores, psychophysical trigeminal dysfunction was present in 10 (35.7%) subjects. Psychophysical olfactory and taste dysfunction were present in 16 (57.1%) and eight (28.6%) participants respectively. Hypercholesterolemia was associated with psychophysical trigeminal dysfunction (mean lateralization performance in hypercholesterolemia 57.7% ± 17.1 vs. 74.1% ± 10.4, <i>p</i> = .008).</p><p><strong>Conclusion: </strong>Intranasal trigeminal impairment is present in nearly one-third of aging adults when assessed by psychophysical methods but is under-recognized. Hyperlipidemia may be associated with trigeminal impairment. Future inquiries should better characterize these findings in larger and prospective cohorts.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":" ","pages":"413-420"},"PeriodicalIF":2.5000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Rhinology & Allergy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/19458924241274973","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/21 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Intranasal trigeminal function is important in detecting environmental stimuli. The impact of age-associated chemosensory dysfunction upon taste and olfaction is well described, but an understanding of trigeminal loss (chemesthesis) is lacking.

Objective: The goal of this study was to characterize trigeminal function in a cohort of older adults and explore potential impacts.

Methods: Twenty-eight participants over 50 years of age were recruited from the community as part of an aging cohort study. This nested cohort completed chemosensory questionnaires, patient-reported outcome measures (PROMs), and psychophysical testing for taste (taste strips), olfaction (Sniffin' Sticks), and trigeminal function (eucalyptol lateralization). Data were analyzed for associations between trigeminal function, olfactory, and taste psychophysical performance, patient-reported metrics, and demographic risk factors.

Results: Patient-reported trigeminal impairment is less severe than other chemosensory loss, with mean visual analog scores (VAS, rated 0-100 from least to most severe) for smell (32.9 ± 34.2), taste (20.6 ± 28.4), and trigeminal sensation (9.5 ± 12.8). Despite low VAS scores, psychophysical trigeminal dysfunction was present in 10 (35.7%) subjects. Psychophysical olfactory and taste dysfunction were present in 16 (57.1%) and eight (28.6%) participants respectively. Hypercholesterolemia was associated with psychophysical trigeminal dysfunction (mean lateralization performance in hypercholesterolemia 57.7% ± 17.1 vs. 74.1% ± 10.4, p = .008).

Conclusion: Intranasal trigeminal impairment is present in nearly one-third of aging adults when assessed by psychophysical methods but is under-recognized. Hyperlipidemia may be associated with trigeminal impairment. Future inquiries should better characterize these findings in larger and prospective cohorts.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
老年人的鼻内三叉神经功能。
背景:鼻内三叉神经功能对检测环境刺激非常重要。与年龄相关的化学感觉功能障碍对味觉和嗅觉的影响已被充分描述,但对三叉神经功能缺失(化学合成)却缺乏了解:本研究的目的是描述一组老年人的三叉神经功能,并探讨其潜在影响:作为老龄化队列研究的一部分,从社区招募了 28 名 50 岁以上的参与者。这个嵌套队列完成了化学感觉问卷、患者报告结果测量(PROMs)以及味觉(味条)、嗅觉(嗅棒)和三叉神经功能(桉叶油醇侧化)的心理物理测试。对数据进行了分析,以确定三叉神经功能、嗅觉和味觉心理物理表现、患者报告的指标以及人口统计学风险因素之间的关联:结果:患者报告的三叉神经功能损害不如其他化学感觉缺失严重,嗅觉(32.9 ± 34.2)、味觉(20.6 ± 28.4)和三叉神经感觉(9.5 ± 12.8)的平均视觉模拟评分(VAS,从最轻到最重的评分为 0-100)。尽管 VAS 评分较低,但仍有 10 名受试者(35.7%)出现了三叉神经心理物理功能障碍。分别有 16 名(57.1%)和 8 名(28.6%)受试者出现心理物理嗅觉和味觉功能障碍。高胆固醇血症与心理物理三叉神经功能障碍有关(高胆固醇血症患者的平均侧化表现为 57.7% ± 17.1 vs. 74.1% ± 10.4,p = .008):结论:通过心理物理方法评估,近三分之一的老龄成年人存在鼻内三叉神经功能障碍,但却未得到充分认识。高脂血症可能与三叉神经功能损害有关。未来的研究应在更大规模的前瞻性队列中更好地描述这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
5.60
自引率
11.50%
发文量
82
审稿时长
4-8 weeks
期刊介绍: The American Journal of Rhinology & Allergy is a peer-reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials, and review articles.
期刊最新文献
Dupilumab Treatment for Aspirin-Exacerbated Respiratory Disease in a Real-World Setting: Impact on Quality of Life and Healthcare Utilization. The Effect of the Nasal Structure on the Olfactory Cleft Airflow: A Systematic Review. Common Cold Coronavirus 229E Induces Higher Interferon Stimulating Gene Responses in Human Nasal Epithelial Cells from Patients with Chronic Rhinosinusitis with Polyposis. Doing the Rhinologic Work, From Humans to Mice to Robots. Endoplasmic Reticulum Stress Promotes Telomerase Reverse Transcriptase Expression Contributes to Development of Allergic Rhinitis.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1