Patient characteristics and treatment patterns of patients with locally advanced or metastatic HER2-low breast cancer, a single site descriptive study.

IF 3 3区 医学 Q2 ONCOLOGY Breast Cancer Research and Treatment Pub Date : 2024-12-01 Epub Date: 2024-08-22 DOI:10.1007/s10549-024-07458-9
Connor Willis, Chia Jie Tan, Anindit Chhibber, Alexandre H Watanabe, Clara Lam, Sandhya Mehta, Jackie Kwong, Leah Park, Melissa Pavilack-Kirker, Xiaoqing Xu, Kristen Kelley, David Stenehjem
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Abstract

Purpose: To evaluate the prevalence and characteristics of different HER2 categories among patients with advanced breast cancer (aBC) and describe treatment patterns and outcomes of those with HER2-low disease.

Methods: A retrospective cohort study was conducted via chart review at the Huntsman Cancer Institute, including patients diagnosed with aBC (stages IIIB, IIIC and IV) between 2010 and 2019. All patients with IHC1+ were considered HER2-low unless FISH was positive. Patients with IHC2+ were only classified as HER2-low if a negative FISH was documented. The prevalence and characteristics of each HER2 category were reported. Treatment patterns and survival outcomes of HER2-low patients who received first line treatment in 2017 or later were presented.

Results: A total of 240 of 414 patients (58%) with aBC were HER2-low, with the majority of patients (83%) classified as hormone receptor (HR)-positive. In first line, most HR-positive patients received endocrine therapy with chemotherapy for stage IIIB/IIIC (47%) and with CDK4/6 inhibitors for stage IV breast cancer (50%) Most HR-negative patients received chemotherapy alone (92% for stage IIIB/IIIC, 60% for stage IV). In second line, chemotherapy alone was the most common modality (21.4% for HR-positive; 45.5% for HR-negative). Median overall survival was 37.7 months while median progression-free survival from first line was 18.0 months, decreasing to 8.0 months in second line.

Conclusion: A substantial proportion of patients previously classified as HER2-negative have low but detectable HER2 expression and may benefit from novel HER2-directed agents, which have demonstrated clinical benefit in this population post-chemotherapy.

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局部晚期或转移性 HER2 低水平乳腺癌患者的特征和治疗模式,一项单点描述性研究。
目的:评估晚期乳腺癌(aBC)患者中不同HER2类别的患病率和特征,并描述HER2低的患者的治疗模式和结果:亨斯迈癌症研究所通过病历审查开展了一项回顾性队列研究,研究对象包括2010年至2019年期间确诊的aBC(IIIB、IIIC和IV期)患者。所有 IHC1+ 患者均被视为 HER2 低,除非 FISH 呈阳性。IHC2+患者只有在FISH阴性的情况下才会被归类为HER2-low。报告了每个 HER2 类别的患病率和特征。报告了2017年或之后接受一线治疗的HER2-low患者的治疗模式和生存结果:在414例aBC患者中,共有240例(58%)为HER2低,其中大部分患者(83%)被归类为激素受体(HR)阳性。在一线治疗中,大多数 HR 阳性患者接受内分泌治疗,IIIB/IIIC 期患者接受化疗(47%),IV 期乳腺癌患者接受 CDK4/6 抑制剂治疗(50%),大多数 HR 阴性患者仅接受化疗(IIIB/IIIC 期 92%,IV 期 60%)。在二线治疗中,单纯化疗是最常见的方式(HR 阳性患者为 21.4%;HR 阴性患者为 45.5%)。中位总生存期为37.7个月,一线治疗的中位无进展生存期为18.0个月,二线治疗的中位无进展生存期降至8.0个月:结论:相当一部分以前被归类为HER2阴性的患者具有较低但可检测到的HER2表达,他们可能会从新型HER2导向药物中获益,这些药物已在化疗后的这类人群中显示出临床获益。
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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
342
审稿时长
1 months
期刊介绍: Breast Cancer Research and Treatment provides the surgeon, radiotherapist, medical oncologist, endocrinologist, epidemiologist, immunologist or cell biologist investigating problems in breast cancer a single forum for communication. The journal creates a "market place" for breast cancer topics which cuts across all the usual lines of disciplines, providing a site for presenting pertinent investigations, and for discussing critical questions relevant to the entire field. It seeks to develop a new focus and new perspectives for all those concerned with breast cancer.
期刊最新文献
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