Evaluation of the protective effect of Curcuma longa and PPARγ agonist, pioglitazone on paraquat-induced lung injury in rats

IF 3.1 4区医学 Q3 IMMUNOLOGY Immunity, Inflammation and Disease Pub Date : 2024-08-22 DOI:10.1002/iid3.70001

Mohammad Hossein Eshaghi Ghalibaf, Mohammad Ehsan Taghavi zadeh Yazdi, Mona Mansourian, Nema Mohammadian Roshan, Mohammad Hossein Boskabady

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Abstract

Background

The inhalation of paraquat (PQ), one of the most widely used herbicides in the world, can result in lung injury. Curcuma longa (Cl) has long history in traditional and folk medicine for the treatment of a wide range of disorders including respiratory diseases.

Aim

The aim of the present work was to evaluate the preventive effect of Cl on inhaled PQ-induced lung injury in rats.

Methods

Male Wistar rats were divided into 8 groups (n = 7), one group exposed to saline (control) and other groups exposed to PQ aerosol. Saline (PQ), Cl extract, (two doses), curcumin (Cu), pioglitazone (Pio), and the combination of Cl-L + Pio and dexamethasone (Dex) were administered during the exposure period to PQ. Total and differential white blood cell (WBC) counts, oxidant and antioxidant indicators in the bronchoalveolar lavage (BALF), interleukin (IL)-10, and tumor necrosis alpha (TNF-α) levels in the lung tissues, lung histologic lesions score, and air way responsiveness to methacholine were evaluated.

Results

WBC counts (Total and differential), malondialdehyde level, tracheal responsiveness (TR), IL-10, TNF-α and histopathological changes of the lung were markedly elevated but total thiol content and the activities of catalase and superoxide dismutase were decreased in the BALF in the PQ group. Both doses of Cl, Cu, Pio, Cl-L + Pio, and Dex markedly improved all measured variables in comparison with the PQ group.

Conclusion

CI, Pio, and Cl-L + Pio improved PQ-induced lung inflammation and oxidative damage comparable with the effects of Dex.

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评估姜黄和 PPARγ 激动剂吡格列酮对百草枯引起的大鼠肺损伤的保护作用

背景：百草枯（PQ）是世界上最广泛使用的除草剂之一，吸入百草枯会导致肺损伤。莪术（Cl）在传统和民间医学中有着悠久的历史，可用于治疗包括呼吸系统疾病在内的多种疾病。目的：本研究旨在评估莪术对吸入百草枯引起的大鼠肺损伤的预防作用：雄性 Wistar 大鼠分为 8 组（n = 7），一组暴露于生理盐水（对照组），另一组暴露于 PQ 气溶胶。在暴露于 PQ 期间，分别给予生理盐水（PQ）、Cl 提取物（两种剂量）、姜黄素（Cu）、吡格列酮（Pio）以及 Cl-L + Pio 和地塞米松（Dex）的组合。对白细胞总数和差值、支气管肺泡灌洗液（BALF）中的氧化剂和抗氧化剂指标、肺组织中的白细胞介素（IL）-10和肿瘤坏死α（TNF-α）水平、肺组织学病变评分以及气道对甲氧胆碱的反应性进行了评估：结果：PQ 组白细胞计数（总数和差值）、丙二醛水平、气管反应性（TR）、IL-10、TNF-α 和肺组织病理学变化明显升高，但 PQ 组 BALF 中总硫醇含量、过氧化氢酶和超氧化物歧化酶活性降低。与 PQ 组相比，两种剂量的 Cl、Cu、Pio、Cl-L + Pio 和 Dex 均明显改善了所有测量变量：结论：CI、Pio 和 Cl-L + Pio 对 PQ 诱导的肺部炎症和氧化损伤的改善效果与 Dex 相当。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology