Impact of excessive sucrose intake on mouse behavior across different developmental stages.

IF 1.6 4区 医学 Q4 NEUROSCIENCES Neuroreport Pub Date : 2024-10-02 Epub Date: 2024-08-01 DOI:10.1097/WNR.0000000000002085
Ye-Jin Kim, Jae-Won Jung, Kyung-A Lee, Young-A Lee
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Abstract

This study aimed to elucidate the effects of sucrose (SUC) consumption on neurodevelopmental processes through behavioral changes in rodents and determine whether these effects could be because of sweet taste, energy supply, or both. Mice were divided into five groups based on the time of SUC or sucralose (SUR, a noncaloric sweetener) administration: for 6 days from gestation day (GTD) 7, to birth from GTD13 and for 15 days from postnatal day (PND) 21, PND38, and PND56. SUC and SUR administration did not impact body weight. However, food intake in the PND56 group and water intake in the GTD13 and PND56 groups were increased by SUC and SUR administration. Amphetamine (0.5, 1, 2, and 3 mg/kg), a dopamine reuptake inhibitor, administration to assess alterations in the dopaminergic system induced increases in distance traveled after SUC administration in the GTD13 and PND21 groups compared with that in the control (vehicle administration) group. In contrast, the SUR group showed a decrease in the distance traveled in the PND56 group. Although there were no differences in locomotor activity and foraging behavior, SUC preference increased in the SUC group regarding the GTD13 and PND38 groups. The correlations between SUC preference and foraging behavior and between SUC preference and amphetamine response varied in both groups according to the developmental stage. Excessive SUC consumption might affect neural function at different developmental stages, as it could affect brain function through complex mechanisms involving sweet taste and energy supply and influence the dopaminergic system.

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摄入过量蔗糖对小鼠不同发育阶段行为的影响
本研究旨在通过啮齿类动物的行为变化来阐明食用蔗糖(SUC)对神经发育过程的影响,并确定这些影响是否可能是甜味、能量供应或两者共同造成的。根据服用 SUC 或三氯蔗糖(SUR,一种非热量甜味剂)的时间将小鼠分为五组:从妊娠第 7 天起服用 6 天,从妊娠第 13 天起服用至出生,以及从出生后第 21 天、第 38 天和第 56 天起服用 15 天。服用 SUC 和 SUR 不会影响体重。但是,在 PND56 组,SUC 和 SUR 会增加 GTD13 和 PND56 组的食物摄入量和水摄入量。安非他明(0.5、1、2和3毫克/千克)是一种多巴胺再摄取抑制剂,用于评估多巴胺能系统的变化。与对照组(给药)相比,GTD13组和PND21组在给药SUC后的行走距离增加。相比之下,SUR组在PND56组的行走距离有所减少。虽然运动活动和觅食行为没有差异,但 SUC 组对 SUC 的偏好在 GTD13 和 PND38 组有所增加。SUC偏好与觅食行为之间的相关性以及SUC偏好与苯丙胺反应之间的相关性在两组中因发育阶段而异。过量摄入SUC可能会影响不同发育阶段的神经功能,因为它可能通过涉及甜味和能量供应的复杂机制影响大脑功能,并影响多巴胺能系统。
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来源期刊
Neuroreport
Neuroreport 医学-神经科学
CiteScore
3.20
自引率
0.00%
发文量
150
审稿时长
1 months
期刊介绍: NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.
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