The role of 25-OH vitamin D in Alzheimer's disease through Mendelian randomization and MRI.

IF 7.3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL QJM: An International Journal of Medicine Pub Date : 2025-01-01 DOI:10.1093/qjmed/hcae166

Ling-Ling Fu, Tobias Vollkommer, Sandra Fuest, Martin Gosau, Hongchao Feng, Ming Yan, Ralf Smeets, Simon Burg, Reinhard E Friedrich

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Abstract

Introduction: The mechanism underlying the relationship between Alzheimer's disease (AD) and minerals (serum calcium, copper, iron, magnesium, zinc), vitamins (25-OH vitamin D, vitamin A1 [retinol], B9 [folic acid], B12, C) is unclear.

Methods: In a two-step Mendelian randomization analysis, the association between positive nutritional elements and 3935 magnetic resonance images (MRI) phenotypes was examined, and the mediation proportion was calculated. Horizontal pleiotropy and heterogeneity of MR were assessed using MR-Egger, Cochran's Q test, MR-PRESSO. RESULTS: 25-OH vitamin D (P = 0.0019, OR = 0.6179, 95% CI = 0.4562-0.8368, inverse weighted variance [IVW]) is negatively associated with AD among 10 nutrients. The mediation proportion of the effect of vitamin D on AD mediated by IDP_dMRI_TBSS_L3_Superior_fronto-occipital_fasciculus_L was ∼7.08%.

Discussion: Our results support 25-OH vitamin D as a causal protective factor for Alzheimer disease. It was found that the Superior_fronto-occipital_fasciculus_L may play a minimal mediating role.

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通过孟德尔随机化和核磁共振成像研究 25-OH 维生素 D 在阿尔茨海默病中的作用。

导言：阿尔茨海默病（AD）与矿物质（血清钙、铜、铁、镁、锌）、维生素（25-OH维生素D、维生素A1[视黄醇]、B9[叶酸]、B12、C）之间的关系机制尚不清楚：在两步孟德尔随机分析中，研究了积极营养元素与 3935 种 MRI 表型之间的关联，并计算了中介比例。结果：在 10 种营养素中，25-OH 维生素 D（p = 0.0019，OR = 0.6179，95% CI = 0.4562-0.8368，IVW）与 AD 负相关。IDP_dMRI_TBSS_L3_Superior_fronto-occipital_fasciculus_L介导的维生素D对AD影响的中介比例约为7.08%：我们的研究结果支持 25-OH 维生素 D 是阿尔茨海默病的因果保护因素。研究发现，颞叶上部_前枕叶_筋膜_L可能只发挥了极小的中介作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

QJM: An International Journal of Medicine 医学-医学：内科

CiteScore

6.90

自引率

5.30%

发文量

263

审稿时长

4-8 weeks

期刊介绍： QJM, a renowned and reputable general medical journal, has been a prominent source of knowledge in the field of internal medicine. With a steadfast commitment to advancing medical science and practice, it features a selection of rigorously reviewed articles. Released on a monthly basis, QJM encompasses a wide range of article types. These include original papers that contribute innovative research, editorials that offer expert opinions, and reviews that provide comprehensive analyses of specific topics. The journal also presents commentary papers aimed at initiating discussions on controversial subjects and allocates a dedicated section for reader correspondence. In summary, QJM's reputable standing stems from its enduring presence in the medical community, consistent publication schedule, and diverse range of content designed to inform and engage readers.

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