Urinary biomarkers NG AL and beta-2 microglobulin in children with type 1 diabetes mellitus.

IF 1.3 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Journal of Pediatric Endocrinology & Metabolism Pub Date : 2024-08-20 Print Date: 2024-09-25 DOI:10.1515/jpem-2024-0172

Nimisha Sachan, Aashima Dabas, Mukta Mantan, Pradeep K Dabla

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Abstract

Objectives: To study the urinary neutrophil gelatinase-associated lipocalin (NGAL) and beta-2-microglobulin (β2M) levels as markers of tubular damage in children with type 1 diabetes (T1DM).

Methods: Forty T1DM children and 40 age-matched controls were enrolled. Subjects with coexisting kidney disorder, intake of oral glucose lowering drugs and syndromic diabetes mellitus were excluded. Fasting plasma glucose, glycated hemoglobin (HbA_1c), kidney function, urinary albumin-creatinine ratio (UACR), NGAL and β2M were measured and compared in cases and controls.

Results: The median (IQR) age of cases and controls was 10.6 (8, 14.2) and 10.7 (8.4, 13.7) years, respectively. Cases had disease duration of 4 (3, 6.8) years and HbA_1c 10.9 (9, 13.1) %. Microalbuminuria was seen in 14 (35 %). Median (IQR) levels of UACR were higher in cases than controls [19.38 (10.27, 35.26) and 6.49 (3.10, 11.65) µg/mg; p<0.001], similarly NGAL/creatinine [352.21 (191.49, 572.45) and 190.54 (125.91, 322.83) ng/mg; p=0.006], unlike β2M/creatinine [1.7 (0.43, 6.02) and 2.12 (1.05, 4.47) µg/mg; p=0.637]. Children with higher HbA_1c (≥10 %) had higher urinary ACR and tubular biomarkers than HbA_1c<10 % (p>0.05). Urinary ACR showed positive correlation with NGAL/creatinine (r=0.38, p=0.019) and β2M/creatinine (r=0.42, p=0.009).

Conclusions: Urinary biomarkers NGAL and β2M were elevated in the presence of normal urinary microalbumin levels suggestive of early tubular damage in T1DM.

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1 型糖尿病患儿尿液生物标记物 NG AL 和 beta-2 微球蛋白。

研究目的研究作为1型糖尿病（T1DM）儿童肾小管损伤标志物的尿液中性粒细胞明胶酶相关脂质钙蛋白（NGAL）和β-2-微球蛋白（β2M）水平：方法：40 名 T1DM 儿童和 40 名年龄匹配的对照组参加了研究。方法：40 名 T1DM 儿童和 40 名年龄匹配的对照组受试者，排除合并肾脏疾病、服用口服降糖药和合并糖尿病的受试者。对病例和对照组的空腹血糖、糖化血红蛋白（HbA1c）、肾功能、尿白蛋白-肌酐比值（UACR）、NGAL和β2M进行了测量和比较：病例和对照组的中位（IQR）年龄分别为 10.6（8，14.2）岁和 10.7（8.4，13.7）岁。病例的病程为 4 (3, 6.8) 年，HbA1c 为 10.9 (9, 13.1) %。14例（35%）患者出现微量白蛋白尿。病例的 UACR 中位数（IQR）水平高于对照组 [19.38 (10.27, 35.26) µg/mg 和 6.49 (3.10, 11.65) µg/mg；p1c（≥10 %）的尿 ACR 和肾小管生物标志物高于 HbA1c0.05）。尿 ACR 与 NGAL/肌酐（r=0.38，p=0.019）和 β2M/肌酐（r=0.42，p=0.009）呈正相关：结论：在尿微量白蛋白水平正常的情况下，尿液生物标志物 NGAL 和 β2M 升高，提示 T1DM 早期肾小管损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Endocrinology & Metabolism 医学-内分泌学与代谢

CiteScore

2.70

自引率

7.10%

发文量

176

审稿时长

3-6 weeks

期刊介绍： The aim of the Journal of Pediatric Endocrinology and Metabolism (JPEM) is to diffuse speedily new medical information by publishing clinical investigations in pediatric endocrinology and basic research from all over the world. JPEM is the only international journal dedicated exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology in its broadest sense, which is needed at this time of rapid expansion of the field of endocrinology. JPEM publishes Reviews, Original Research, Case Reports, Short Communications and Letters to the Editor (including comments on published papers),. JPEM publishes supplements of proceedings and abstracts of pediatric endocrinology and diabetes society meetings.