Amy Metcalfe, Zoe F. Cairncross, Joel G. Ray, Lorraine Shack, Gregg Nelson, Christine M. Friedenreich, Khokan Sikdar, Sarka Lisonkova, Carly A. McMorris, Parveen Bhatti, Deshayne B. Fell
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引用次数: 0
Abstract
Objective
To assess whether procedural-induced abortion or provider-initiated preterm delivery are associated with improved survival in pregnant people with cancer.
Design
Retrospective population-based cohort study.
Setting
Provinces of Alberta and Ontario, Canada, 2003–2016.
Population
Females aged 18–50 years diagnosed with cancer at <20 weeks' (for the assessment of procedural-induced abortion) or <37 weeks' gestation (for the assessment of provider-initiated delivery).
Methods
Cox proportional hazard models assessed all-cause mortality in relation to procedural-induced abortion and provider-initiated preterm delivery, adjusting for cancer site, stage at diagnosis and age. Meta-analysis pooled the results across both provinces.
Main Outcome Measures
All cause mortality.
Results
There were 512 pregnant people diagnosed with cancer at <20 weeks' gestation and 782 diagnosed with cancer at <37 weeks' gestation. Neither procedural-induced abortion (adjusted hazard ratio [aHR] = 1.39, 95% CI: 0.32–6.17) nor provider-initiated preterm delivery (aHR = 1.17, 95% CI: 0.76–1.81) were associated with improved survival following adjustment for age, stage at diagnosis and cancer site.
Conclusions
Neither procedural-induced abortion nor provider-initiated preterm birth was associated with improved survival in pregnant people diagnosed with cancer; however, these obstetric interventions are highly personal decisions best decided by the pregnant person in consultation with their care providers.
期刊介绍：
BJOG is an editorially independent publication owned by the Royal College of Obstetricians and Gynaecologists (RCOG). The Journal publishes original, peer-reviewed work in all areas of obstetrics and gynaecology, including contraception, urogynaecology, fertility, oncology and clinical practice. Its aim is to publish the highest quality medical research in women''s health, worldwide.
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