Expression and prognosis of DSG-2, CXADR, CD46 in head and neck squamous cell carcinoma

IF 2.9 4区医学 Q2 PATHOLOGY Pathology, research and practice Pub Date : 2024-08-15 DOI:10.1016/j.prp.2024.155541

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Abstract

Objectives

Investigating the expression and prognostic significance of adenovirus receptors DSG-2, CXADR and CD46 in head and neck cancer.

Methods

104 patients with HNSCC (77 OPSCC, 27 LSCC) were retrospectively included in the study. Immunohistochemical staining was performed on all selected slides to detect the expression of DSG-2, CXADR, CD46 and the immunoreactive score (IRS) was determined from the number of positively stained tumor cells and their staining intensity. Furthermore, the respective HPV status was determined by immunohistochemical staining against p16 and HPV-PCR.

Results

81.7 % of the tumors showed DSG-2, 34.6 % of the tumors showed CXADR and 57.7 % of the tumors showed CD46 expression. A high DSG-2 IRS correlated significantly with an advanced tumor size (p= 0.003), increased grading (p=0.012) and positive HPV status (p=0.024) in OPSCC. A high CXADR IRS was significantly associated with a positive lymph node status (p= 0.041) in LSCC and an advanced AJCC stage (p= 0.012) and a positive HPV status (p= 0.009) in OPSCC. No significant correlation could be shown regarding CD46 expression and clinical tumor data. There was no effect of DSG-2, CXADR, and CD46 expression on 5-year overall and on 5-year disease-free survival.

Conclusion

No prognostic significance of the expression of DSG-2, CXADR or CD46 in HNSCC was seen. DSG-2, CXADR and CD46 are expressed in HNSCC, so that optimization of oncotherapy with adenoviral vectors appears promising. Due to the significantly increased expression of DSG-2 and CXADR in advanced OPSCC tumors, there is potential for optimizing oncotherapy here in particular.

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头颈部鳞状细胞癌中 DSG-2、CXADR 和 CD46 的表达与预后

目的探讨腺病毒受体DSG-2、CXADR和CD46在头颈癌中的表达及其预后意义。方法回顾性纳入104例HNSCC患者（77例OPSCC，27例LSCC）。对所有选取的切片进行免疫组化染色，检测DSG-2、CXADR和CD46的表达，并根据阳性染色肿瘤细胞的数量及其染色强度确定免疫反应评分（IRS）。结果81.7%的肿瘤显示 DSG-2，34.6%的肿瘤显示 CXADR，57.7%的肿瘤显示 CD46。高DSG-2 IRS与OPSCC的肿瘤大小（p= 0.003）、分级（p=0.012）和HPV阳性（p=0.024）显著相关。在 LSCC 中，高 CXADR IRS 与淋巴结阳性状态（p= 0.041）显著相关；在 OPSCC 中，高 CXADR IRS 与 AJCC 分期晚期（p= 0.012）和 HPV 阳性状态（p= 0.009）显著相关。CD46 表达与临床肿瘤数据无明显相关性。DSG-2、CXADR和CD46的表达对5年总生存期和5年无病生存期没有影响。DSG-2、CXADR和CD46在HNSCC中均有表达，因此利用腺病毒载体优化肿瘤治疗似乎很有前景。由于DSG-2和CXADR在晚期OPSCC肿瘤中的表达明显增加，因此特别有可能在此优化肿瘤治疗。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.