Embryo multinucleation: detection, possible origins, and implications for treatment.

IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Human reproduction Pub Date : 2024-11-01 DOI:10.1093/humrep/deae186
Giovanni Coticchio, Cristina Lagalla, Marilena Taggi, Danilo Cimadomo, Laura Rienzi
{"title":"Embryo multinucleation: detection, possible origins, and implications for treatment.","authors":"Giovanni Coticchio, Cristina Lagalla, Marilena Taggi, Danilo Cimadomo, Laura Rienzi","doi":"10.1093/humrep/deae186","DOIUrl":null,"url":null,"abstract":"<p><p>Cell cycle regulation is crucial to assure expansion of a cell population, while preserving genome integrity. This notion is especially relevant to fertilization and early embryo development, a time when the cell cycle transforms from meiotic into mitotic cycles. Zygote-to-embryo transition is acutely error-prone, causing major developmental perturbations, including cleavage delays, tri- and multi-chotomous cleavages, and cell fragmentation. Another such alteration is bi- and multinucleation, consisting of the simultaneous formation of two or more nuclei at interphase. Indeed, multinucleation affects a large proportion of early human embryos, typically at the two-cell stage. Mechanistically, several factors, including spindle dysfunction, failed cleavage, and cell fusion, may generate this cell anomaly. In assisted reproduction treatment, multinucleation is associated with reduced developmental rates and lower implantation rates in Days 2-3 embryo transfers. However, many multinucleated embryos can develop to the blastocyst stage. In blastocyst transfers, the current evidence does not suggest a major impact of a previous history of multinucleation on the odds of euploidy or successful treatment outcomes. Human embryo multinucleation remains a not-fully-understood but developmentally relevant and intriguing phenomenon which requires further research of its generative mechanisms and clinical implications.</p>","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human reproduction","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/humrep/deae186","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Cell cycle regulation is crucial to assure expansion of a cell population, while preserving genome integrity. This notion is especially relevant to fertilization and early embryo development, a time when the cell cycle transforms from meiotic into mitotic cycles. Zygote-to-embryo transition is acutely error-prone, causing major developmental perturbations, including cleavage delays, tri- and multi-chotomous cleavages, and cell fragmentation. Another such alteration is bi- and multinucleation, consisting of the simultaneous formation of two or more nuclei at interphase. Indeed, multinucleation affects a large proportion of early human embryos, typically at the two-cell stage. Mechanistically, several factors, including spindle dysfunction, failed cleavage, and cell fusion, may generate this cell anomaly. In assisted reproduction treatment, multinucleation is associated with reduced developmental rates and lower implantation rates in Days 2-3 embryo transfers. However, many multinucleated embryos can develop to the blastocyst stage. In blastocyst transfers, the current evidence does not suggest a major impact of a previous history of multinucleation on the odds of euploidy or successful treatment outcomes. Human embryo multinucleation remains a not-fully-understood but developmentally relevant and intriguing phenomenon which requires further research of its generative mechanisms and clinical implications.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
胚胎多核现象:检测、可能的起源和对治疗的影响。
细胞周期调控对于确保细胞群的扩增,同时保持基因组的完整性至关重要。这一概念与受精和早期胚胎发育尤其相关,因为此时细胞周期从减数分裂周期转变为有丝分裂周期。从受精卵到胚胎的转变过程极易出错,会造成严重的发育紊乱,包括裂殖延迟、三裂殖和多裂殖以及细胞破碎。另一种此类改变是双核和多核现象,包括在间期同时形成两个或多个细胞核。事实上,多核现象影响着很大一部分早期人类胚胎,通常发生在两细胞阶段。从机理上讲,包括纺锤体功能障碍、裂解失败和细胞融合在内的多种因素都可能导致这种细胞异常。在辅助生殖治疗中,多核与第 2-3 天胚胎移植中发育率降低和植入率降低有关。然而,许多多核胚胎可以发育到囊胚阶段。在囊胚移植中,目前的证据并不表明先前的多核现象会对非整倍体或成功治疗的几率产生重大影响。人类胚胎多核现象仍未被完全理解,但与发育相关,是一个有趣的现象,需要进一步研究其生成机制和临床影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Human reproduction
Human reproduction 医学-妇产科学
CiteScore
10.90
自引率
6.60%
发文量
1369
审稿时长
1 months
期刊介绍: Human Reproduction features full-length, peer-reviewed papers reporting original research, concise clinical case reports, as well as opinions and debates on topical issues. Papers published cover the clinical science and medical aspects of reproductive physiology, pathology and endocrinology; including andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, early pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues.
期刊最新文献
Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality The role of state-of-the-art IVF care as a marker of societal development Road to in vitro maturation (IVM), from basic science to an informed clinical practice. Embryo multinucleation: detection, possible origins, and implications for treatment.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1