Embryo multinucleation: detection, possible origins, and implications for treatment.

IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Human reproduction Pub Date : 2024-11-01 DOI:10.1093/humrep/deae186
Giovanni Coticchio, Cristina Lagalla, Marilena Taggi, Danilo Cimadomo, Laura Rienzi
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Abstract

Cell cycle regulation is crucial to assure expansion of a cell population, while preserving genome integrity. This notion is especially relevant to fertilization and early embryo development, a time when the cell cycle transforms from meiotic into mitotic cycles. Zygote-to-embryo transition is acutely error-prone, causing major developmental perturbations, including cleavage delays, tri- and multi-chotomous cleavages, and cell fragmentation. Another such alteration is bi- and multinucleation, consisting of the simultaneous formation of two or more nuclei at interphase. Indeed, multinucleation affects a large proportion of early human embryos, typically at the two-cell stage. Mechanistically, several factors, including spindle dysfunction, failed cleavage, and cell fusion, may generate this cell anomaly. In assisted reproduction treatment, multinucleation is associated with reduced developmental rates and lower implantation rates in Days 2-3 embryo transfers. However, many multinucleated embryos can develop to the blastocyst stage. In blastocyst transfers, the current evidence does not suggest a major impact of a previous history of multinucleation on the odds of euploidy or successful treatment outcomes. Human embryo multinucleation remains a not-fully-understood but developmentally relevant and intriguing phenomenon which requires further research of its generative mechanisms and clinical implications.

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胚胎多核现象:检测、可能的起源和对治疗的影响。
细胞周期调控对于确保细胞群的扩增,同时保持基因组的完整性至关重要。这一概念与受精和早期胚胎发育尤其相关,因为此时细胞周期从减数分裂周期转变为有丝分裂周期。从受精卵到胚胎的转变过程极易出错,会造成严重的发育紊乱,包括裂殖延迟、三裂殖和多裂殖以及细胞破碎。另一种此类改变是双核和多核现象,包括在间期同时形成两个或多个细胞核。事实上,多核现象影响着很大一部分早期人类胚胎,通常发生在两细胞阶段。从机理上讲,包括纺锤体功能障碍、裂解失败和细胞融合在内的多种因素都可能导致这种细胞异常。在辅助生殖治疗中,多核与第 2-3 天胚胎移植中发育率降低和植入率降低有关。然而,许多多核胚胎可以发育到囊胚阶段。在囊胚移植中,目前的证据并不表明先前的多核现象会对非整倍体或成功治疗的几率产生重大影响。人类胚胎多核现象仍未被完全理解,但与发育相关,是一个有趣的现象,需要进一步研究其生成机制和临床影响。
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来源期刊
Human reproduction
Human reproduction 医学-妇产科学
CiteScore
10.90
自引率
6.60%
发文量
1369
审稿时长
1 months
期刊介绍: Human Reproduction features full-length, peer-reviewed papers reporting original research, concise clinical case reports, as well as opinions and debates on topical issues. Papers published cover the clinical science and medical aspects of reproductive physiology, pathology and endocrinology; including andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, early pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues.
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